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Spatial and Proteolytic Determinants of Therapeutic Potential in HER2‐Low Breast Cancer
Advanced Science, EarlyView.
Deqian Xie, Wei Dai, Guangzhen Wu
wiley +1 more source
DESpace2 : detection of differential spatial patterns in spatial omics data
Cai P, Robinson MD, Tiberi S.
europepmc +1 more source
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Omics goes spatial epigenomics
Cell, 2022Spatial omics techniques generate spatially resolved, comprehensive data about molecules that define the identity and function of cells in tissues. Epigenetic multiplexing approaches such as Multiplexed Error-robust FISH (MERFISH), introduced by Lu et al.1 in this issue of Cell, now allows researchers to study the epigenomic regulation of gene ...
Florian, Schueder, Joerg, Bewersdorf
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Streamlining spatial omics data analysis with Pysodb
Nature Protocols, 2023Advances in spatial omics technologies have improved the understanding of cellular organization in tissues, leading to the generation of complex and heterogeneous data and prompting the development of specialized tools for managing, loading and visualizing spatial omics data.
Senlin Lin +5 more
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Harnessing computational spatial omics to explore the spatial biology intricacies
Seminars in Cancer Biology, 2023Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our understanding of intricate tissue architectures. However, this rapidly expanding field produces a wealth of diverse and voluminous data, necessitating the evolution of sophisticated computational strategies to unravel inherent patterns.
Zhiyuan, Yuan, Jianhua, Yao
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Advances in Spatial Omics Technologies
Small MethodsAbstractRapidly developing spatial omics technologies provide us with new approaches to deeply understanding the diversity and functions of cell types within organisms. Unlike traditional approaches, spatial omics technologies enable researchers to dissect the complex relationships between tissue structure and function at the cellular or even ...
Tianxiao Hui +4 more
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Spatial-Omics Methods and Applications
Traditional tissue profiling approaches have evolved from bulk studies to single-cell analysis over the last decade; however, the spatial context in tissues and microenvironments has always been lost. Over the last 5 years, spatial technologies have emerged that enabled researchers to investigate tissues in situ for proteins and transcripts without ...Arutha, Kulasinghe +3 more
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