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Application of spatial omics in gastric cancer
Pathology - Research and PracticeGastric cancer (GC), a globally prevalent and lethal malignancy, continues to be a key research focus. However, due to its considerable heterogeneity and complex pathogenesis, the treatment and diagnosis of gastric cancer still face significant challenges.
Erran, Zhu +3 more
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The integration of spatial omics and bioprinting has opened new avenues for studying the spatial organization of cells and tissues, allowing researchers to gain a deeper understanding of cellular interactions and signaling pathways. Organoids spheroids, three-dimensional models that closely mimic the structure and function of human organs, have emerged
Bhumika Iranna Byalahunasishetter +4 more
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Bhumika Iranna Byalahunasishetter +4 more
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Advances in spatial multi-omics in tumors
Tumori JournalSingle-cell techniques have convincingly demonstrated that tumor tissue usually contains multiple genetically defined cell subclones with different gene mutation sets as well as various transcriptional profiles, but the spatial heterogeneity of the microenvironment and the macrobiological characteristics of the tumor ecosystem have not been described.
Junyan Wang +5 more
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Accelerating Drug Development Using Spatial Multi-omics
Cancer DiscoverySummary: Spatial biology approaches enabled by innovations in imaging biomarker platforms and artificial intelligence–enabled data integration and analysis provide an assessment of patient and disease heterogeneity at ever-increasing resolution.
Richard J.A. Goodwin +3 more
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Spatial Omics and Gene Circuits
Spatial transcriptomics is a powerful tool in biomedical research that enables the analysis of gene expression patterns within their spatial context. By providing insights into the spatial organisation of gene expression, this technology can help address limitations in the design of synthetic gene circuits in a controlled manner.Shantagoud Biradar +3 more
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Spatial Omics DataBase (SODB): increasing accessibility to spatial omics data
Nature Methods, 2023openaire +2 more sources
The technological landscape and applications of single-cell multi-omics
Nature Reviews Molecular Cell Biology, 2023Zhiliang Bai, Rahul Satija, Rong Fan
exaly
Investigating spatial dynamics in spatial omics data with StarTrail
Spatial omics technologies revolutionize our view of biological processes within tissues. However, existing methods fail to capture localized, sharp changes characteristic of critical events (e.g. tumor development). Here, we present StarTrail, a novel gradient based method that powerfully defines rapidly changing regions and detects "cliff genes ...Jiawen Chen +7 more
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