Results 31 to 40 of about 64,018 (290)

Tissue characterization at an enhanced resolution across spatial omics platforms with deep generative model

Nature Communications
Recent advances in spatial omics have expanded the spectrum of profiled molecular categories beyond transcriptomics. However, many of these technologies are constrained by limited spatial resolution, hindering our ability to deeply characterize intricate
Bohan Li, Feng Bao, Yimin Hou, Fengji Li, Hongjue Li, Yue Deng, Qionghai Dai   +6 more
doaj   +1 more source

Systems analysis of host-parasite interactions. [PDF]

, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema, Lewis, Nathan E, Swann, Justine, Winzeler, Elizabeth A   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SMART: spatial multi-omic aggregation using graph neural networks and metric learning

Nature Communications
Spatial multi-omics enables the exploration of tissue microenvironments and heterogeneity from the perspective of different omics modalities across distinct spatial domains within tissues.
Zhihua Du, Qiyi Chen, Weiliang Huang, Jinmiao Chen, Xubin Zheng   +4 more
doaj   +1 more source

Eco-evolutionary dynamics in fragmented landscapes [PDF]

, 2017
Peer ...
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core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment

Cellular & Molecular Biology Letters, 2023
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the ...
Xudong Yu, Ruijia Liu, Wenfeng Gao, Xuyun Wang, Yaosheng Zhang   +4 more
doaj   +1 more source

Opportunities and challenges in the application of single-cell and spatial transcriptomics in plants

Frontiers in Plant Science, 2023
Single-cell and spatial transcriptomics have diverted researchers’ attention from the multicellular level to the single-cell level and spatial information.
Ce Chen, Yining Ge, Lingli Lu, Lingli Lu
doaj   +1 more source

An Introduction to Programming for Bioscientists: A Python-based Primer

, 2016
Computing has revolutionized the biological sciences over the past several decades, such that virtually all contemporary research in the biosciences utilizes computer programs.
Ekmekci, Berk, McAnany, Charles E., Mura, Cameron   +2 more
core   +4 more sources

Polymicrobial oral biofilm models: simplifying the complex [PDF]

, 2019
Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions.
Appelbaum, Black, Bradshaw, Bryn Short, Ceri, Christopher Delaney, Darveau, Fitzgerald, Gibbons, Gordon Ramage, Hamilton, Jason L. Brown, John Butcher, Lie, Loesche, Loesche, Marcello Riggio, Mark C. Butcher, Marsh, Marsh, McKee, Miller, Orstavik, Pratten, Russell, Shauna Culshaw, Sudo, Sudo, Tracy Young, William Johnston   +29 more
core   +3 more sources