Results 51 to 60 of about 64,018 (290)

A graph neural network-based spatial multi-omics data integration method for deciphering spatial domains.

PLoS Computational Biology
Recent advancements of spatial sequencing technologies enable measurements of transcriptomic and epigenomic profiles within the same tissue slice, providing an unprecedented opportunity to understand cellular microenvironments.
Congqiang Gao, Chenghui Yang, Lihua Zhang   +2 more
doaj   +1 more source

Applications of multi‐omics analysis in human diseases

MedComm, 2023
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening technologies represented by genomics, transcriptomics, single‐cell transcriptomics, proteomics and metabolomics, spatial transcriptomics, and so on, which play ...
Chongyang Chen, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Xifei Yang, Min Yang, Gong‐Ping Liu   +9 more
doaj   +1 more source

Single-cell technologies: From research to application

The Innovation, 2022
In recent years, more and more single-cell technologies have been developed. A vast amount of single-cell omics data has been generated by large projects, such as the Human Cell Atlas, the Mouse Cell Atlas, the Mouse RNA Atlas, the Mouse ATAC Atlas, and ...
Lu Wen, Guoqiang Li, Tao Huang, Wei Geng, Hao Pei, Jialiang Yang, Miao Zhu, Pengfei Zhang, Rui Hou, Geng Tian, Wentao Su, Jian Chen, Dake Zhang, Pingan Zhu, Wei Zhang, Xiuxin Zhang, Ning Zhang, Yunlong Zhao, Xin Cao, Guangdun Peng, Xianwen Ren, Nan Jiang, Caihuan Tian, Zi-Jiang Chen   +23 more
doaj   +1 more source

Hypothesis exploration with visualization of variance. [PDF]

, 2014
BackgroundThe Consortium for Neuropsychiatric Phenomics (CNP) at UCLA was an investigation into the biological bases of traits such as memory and response inhibition phenotypes-to explore whether they are linked to syndromes including ADHD, Bipolar ...
Bilder, Robert M, Congdon, Eliza, Parker, Douglass Stott   +2 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The active microbial community more accurately reflects the anaerobic digestion process: 16S rRNA (gene) sequencing as a predictive tool [PDF]

, 2018
Background: Amplicon sequencing methods targeting the 16S rRNA gene have been used extensively to investigate microbial community composition and dynamics in anaerobic digestion.
de Vrieze, Jo, Ijaz, Umer Zeeshan, Pinto, Ameet J., Sloan, William T.   +3 more
core   +2 more sources

Spatial mapping of cancer tissues by OMICS technologies

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022
Spatial mapping of heterogeneity in gene expression in cancer tissues can improve our understanding of cancers and help in the rapid detection of cancers with high accuracy and reliability. Significant advancements have been made in recent years in OMICS technologies, which possess the strong potential to be applied in the spatial mapping of biopsy ...
Ahmed R., Augustine R., Valera E., Ganguli A., Mesaeli N., Ahmad I.S., Bashir R., Hasan, Anwarul   +7 more
openaire   +4 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

MultiGATE: integrative analysis and regulatory inference in spatial multi-omics data via graph representation learning

Nature Communications
New spatial multi-omics technologies, which jointly profile transcriptome and epigenome/protein markers for the same tissue section, expand the frontiers of spatial techniques. Here, we introduce MultiGATE, which utilizes a two-level graph attention auto-
Jishuai Miao, Jinzhao Li, Jingxue Xin, Jiajuan Tu, Muyang Ge, Ji Qi, Xiaocheng Zhou, Ying Zhu, Can Yang, Zhixiang Lin   +9 more
doaj   +1 more source