Results 71 to 80 of about 64,018 (290)

Interrogation of imaging-based interspecies dynamics in the oral microbiome

Journal of Oral Microbiology
Background The oral cavity presents a highly dynamic environment where inter-microbial communications play a pivotal role. Understanding the spatial organization of microbial ecosystems has been highlighted on the microbiome and polymicrobial infection ...
Zhenting Xiang, Zi Wang, Nikoo Ghasemi, Yan Wang, Jing Wen, Yuan Liu   +5 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Decoding plant complexity through spatially resolved multi-omics approaches

Discover Plants
Spatial omics has rapidly emerged as a transformative method for decoding the molecular landscape of plant biology by integrating transcriptomic, proteomic, and metabolomic information with precise spatial context.
Suman Dutta
doaj   +1 more source

Artificial Intelligence-Driven Precision Medicine: Multi-Omics and Spatial Multi-Omics Approaches in Diffuse Large B-Cell Lymphoma (DLBCL)

Frontiers in Bioscience-Landmark
In this comprehensive review, we delve into the transformative role of artificial intelligence (AI) in refining the application of multi-omics and spatial multi-omics within the realm of diffuse large B-cell lymphoma (DLBCL) research.
Yanping Shao, Xiuyan Lv, Shuangwei Ying, Qunyi Guo   +3 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Deciphering spatial domains from spatial multi-omics with SpatialGlue

, 2023
Abstract Integration of multiple data modalities in a spatially informed manner remains an unmet need for exploiting spatial multi-omics data. Here, we introduce SpatialGlue, a novel graph neural network with dual-attention mechanism, to decipher spatial domains by capturing the significance of each modality and neighbor graph in cross-omics ...
Yahui Long, Kok Siong Ang, Sha Liao, Raman Sethi, Yang Heng, Chengwei Zhong, Hang XU, Nazihah Husna, Min Jian, Lai Guan Ng, Ao Chen, Nicholas Gascoigne, Xun Xu, Jinmiao Chen   +13 more
openaire   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Single‐Cell and Spatial Multiomics: Applications for Diseases

MedComm
Complex and dynamic networks of molecules are involved in human diseases. ​Single‐cell and spatial multiomics approaches have created new avenues for understanding the pathogenesis and diagnosis of diseases.
Wentao Li, Chao Chen, Xin Zhu, Chenping Zhang   +3 more
doaj   +1 more source

Cellular diversity through space and time: adding new dimensions to GBM therapeutic development

Frontiers in Genetics
The current median survival for glioblastoma (GBM) patients is only about 16 months, with many patients succumbing to the disease in just a matter of months, making it the most common and aggressive primary brain cancer in adults.
Amanda L. Johnson, Amanda L. Johnson, Hernando Lopez-Bertoni, Hernando Lopez-Bertoni, Hernando Lopez-Bertoni, Hernando Lopez-Bertoni   +5 more
doaj   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source