Results 121 to 130 of about 719,902 (313)

Spatial Patterns in Household Demand [PDF]

Econometrica, 1991
This paper discusses economic processes that may give rise to spatial patterns in data and explores the relative merits of alternative modeling approaches when data are spatially correlated. An estimation scheme is presented that allows for spatial random effects and attention is focused on cases in which such a framework may be preferred to the more ...
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An envelope method for analysing sequential pattern formation

, 2000
We examine sequential spatial pattern formation in a tissue interaction model for skin organ morphogenesis. Pattern formation occurs as a front sweeps across the domain leaving in its wake a steady state spatial pattern.
Cruywagen, GC, Maini, P. K., Murray, JD, Murray, J. D., Maini, Philip, Maini, PK, Cruywagen, G. C.   +6 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

A Task-Related EEG Microstate Clustering Algorithm Based on Spatial Patterns, Riemannian Distance, and a Deep Autoencoder

Brain Sciences
Background: The segmentation of electroencephalography (EEG) signals into a limited number of microstates is of significant importance in the field of cognitive neuroscience.
Shihao Pan, Tongyuan Shen, Yongxiang Lian, Li Shi   +3 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

The Commuting Pattern Analysis Of Commuters From Depok City West Java

, 2020
This research aims to analyze the commuting pattern of commuters from Depok City. Quantitative descriptive method was used and survey was conducted in this research.
Khairunisa, Wulan Azahra, Suhardjo, Munandar, Aris   +2 more
core  

Spatiotemporal distribution patterns of cephalopods and their responses to changes in the marine environment in the coastal waters of Zhejiang, China

Frontiers in Marine Science
IntroductionLike pelagic fishes, cephalopods represent fishery resources with high worldwide potential and an important evolutionary node animal group. Thus, exploring the spatial and seasonal variations in cephalopod distribution and their associations ...
Jun Liang, Jun Liang, Yongdong Zhou, Yongdong Zhou, Tian Wu, Feng Chen, Feng Chen, Kaida Xu, Kaida Xu, Guangjie Fang, Yazhou Zhang, Yazhou Zhang   +11 more
doaj   +1 more source