Results 71 to 80 of about 160,073 (300)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Did Zipf Anticipate Socio-Economic Spatial Networks? [PDF]

, 2012
An avalanche of empirical studies has addressed the validity of the rank-size rule (or Zipf’s law) in a multi-city context in many countries. City size in most countries seems to obey Zipf’s law, but the question under which conditions (e.g. sample size,
Reggiani, Aura, Nijkamp, Peter, Nijkamp, P., Reggiani, A.   +3 more
core   +1 more source

Convergence and Divergence in the Evolution of Cat Skulls: Temporal and Spatial Patterns of Morphological Diversity

PLoS ONE, 2012
Studies of biological shape evolution are greatly enhanced when framed in a phylogenetic perspective. Inclusion of fossils amplifies the scope of macroevolutionary research, offers a deep-time perspective on tempo and mode of radiations, and elucidates life-trait changes.
Manabu Sakamoto, Marcello Ruta
openaire   +6 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Influence of subglacial drainage system evolution on glacier surface motion: Haut Glacier d'Arolla, Switzerland [PDF]

, 2002
The relationship between the evolution of subglacial drainage system morphology and spatial patterns of glacier surface velocity was investigated using dye tracing experiments and ground surveying throughout the 1995 melt season at Haut Glacier d'Arolla,
Ian Willis, Sharp, M., Wohlleben, T., Peter Nienow, Mair, D., Martin Sharp, Willis, I., Trudy Wohlleben, Douglas Mair, Nienow, P.   +9 more
core   +1 more source

A Study of Spatial Evolution Patterns of Tourist Destinations Disaster Risks [PDF]

Journal of Risk Analysis and Crisis Response, 2018
Due to the strong suddenness, large destruction and wide impact, disasters can cause serious property and safety loss to tourists, damage significantly tourism infrastructure, properties and resources. In order to prevent disaster and to better understand future disaster risk evolution, we have built a comprehensive disaster risk evaluation model using
Yingyue Sun, Qingshan Yang, Peng Chen
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Evolution of spatial cognition: sex-specific patterns of spatial behavior predict hippocampal size. [PDF]

Proceedings of the National Academy of Sciences, 1990
In a study of two congeneric rodent species, sex differences in hippocampal size were predicted by sex-specific patterns of spatial cognition. Hippocampal size is known to correlate positively with maze performance in laboratory mouse strains and with selective pressure for spatial memory among passerine bird species.
L F, Jacobs, S J, Gaulin, D F, Sherry, G E, Hoffman   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Spatial and spatio-temporal analysis of Salmonella infection in dairy herds in England and Wales [PDF]

, 2009
Using data from a cohort study conducted by the Veterinary Laboratories Agency (VLA), evidence of spatial clustering at distances up to 30 kin was found for S. Agama and S.
Fenton, S, Fenton, S. E., Evans, S. J., Vink, D, French, N. P., Davison, S, French, N, Vink, W. D., Davison, H. C., Clough, H. E., Diggle, P. J., Diggle, PJ, Evans, S, Clough, H   +13 more
core   +1 more source