Results 81 to 90 of about 160,073 (300)

SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution

PLoS Computational Biology, 2014
The sensitivity of massively-parallel sequencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells harboring distinct mutations. A fine resolution view of this clonal architecture provides insight into tumor heterogeneity, evolution, and treatment response, all of which may have clinical implications. Single tumor
Christopher A. Miller 0002, Brian S. White, Nathan D. Dees, Malachi Griffith, John S. Welch, Obi L. Griffith, Ravi Vij, Michael H. Tomasson, Timothy A. Graubert, Matthew J. Walter, Matthew J. Ellis, William S. Schierding, John F. DiPersio, Timothy J. Ley, Elaine R. Mardis, Richard K. Wilson, Li Ding   +16 more
openaire   +5 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Coexistence of fraternity and egoism for spatial social dilemmas

, 2012
We have studied an evolutionary game with spatially arranged players who can choose one of the two strategies (named cooperation and defection for social dilemmas) when playing with their neighbors. In addition to the application of the usual strategies
Szabó, György, Szolnoki, Attila, Czakó, Lilla   +2 more
core   +1 more source

Population Distribution in Guizhou’s Mountainous Cities: Evolution of Spatial Pattern and Driving Factors

Land
Guizhou is a typical mountainous province and is also one of the lowland regions in China that has attracted a population influx. Here, using population density data from 2000 to 2020 as the basic dataset and the coefficient of variation method and ...
Kui Ying, Lin Ha, Yaohua Kuang, Jinhong Ding   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

General Pattern Formation in Recursive Dynamical Systems Models in Economics [PDF]

This paper presents a fairly general treatment of recursive infinite horizon forward looking optimizing systems on infinite dimensional spatial domains.
William Brock, Anastasios Xepapadeas
core   +2 more sources

Research on the evolutionary characteristics and mechanism of production-living-ecological space in Shanxi Province, China

Scientific Reports
An investigation of the evolutionary characteristics and internal driving mechanisms of territorial space since the reform and opening up is essential.
Hao Li, Pengfei Zhang, Lei Zhang, Jun Yang, Xiangsheng An   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Temporal and Spatial Evolution of Public–Private Partnership (PPP) Project Risks in China: 2003–2019

Advances in Civil Engineering
The implementation of public–private partnership (PPP) is perturbed by multiple factors, and it is difficult for the Chinese government to fully control the risks of PPP projects.
Yanwei Wang, Lili Gong, Shanfeng Zheng, Xiaoqing Han, Jiajin Zhang, Yi Huang   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source