Results 41 to 50 of about 1,167,036 (308)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transition of mobility in companies – A semi-systematic literature review and bibliographic analysis on corporate mobility and its management

Transportation Research Interdisciplinary Perspectives, 2021
Advancement measures and negative externalities of the current transport system have been extensively researched but significant changes concerning greenhouse gas (GHG) emission reduction is yet to be achieved. The expected mobility changes, triggered by
Tobias Gorges, Christian Holz-Rau
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An open risk index with learning indicators from OSM-tags, developed by machine learning and trained with the WorldRiskIndex [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
While climate change is already a real issue in many parts of the world, it is even more threatening the well-being of future generations. The SDG 1.5 explicitly aims to reduce the vulnerability and exposure to climate related hazards by 2030.
D. Feldmeyer, H. Sauter, J. Birkmann
doaj   +1 more source

Constructions of sustainability and spatial planning: the case of Dalton Flatts, County Durham, planning inquiry [PDF]

, 2005
This paper explores the constructions of sustainability within a recent land use planning event. The focus is upon the discursive processes employed by key actors and agents in constructing concepts of sustainability during the local planning inquiry ...
Hattingh Smith, A
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Between author’s dreams and client’s wishes

Actas de Arquitectura Religiosa Contemporánea
Contemporary praxis of church construction in the Serbian Orthodox Church (SOC) and the client-architect relationship are conditioned by Church tradition and regulations.
Božidar Mani´c , Ana Nikovi´c, Boško Josimovi´c   +2 more
doaj   +1 more source

Relationship between traditional and contemporary elements in the architecture of Orthodox churches at the turn of the millennium [PDF]

Facta Universitatis. Series: Architecture and Civil Engineering, 2015
The paper will present the contemporary practice of church architecture in Bulgarian, Romanian, Russian and Greek orthodox churches, at the end of the XX and the beginning of the XXI century, and analyse the relationship of traditional and ...
Manić Božidar, Niković Ana, Marić Igor   +2 more
doaj   +1 more source

Increasing societal discomfort about a dominant restrictive planning discourse on open space in Flanders/Belgium [PDF]

, 2010
The specific spatial context in the densely urbanised northern part of Belgium, Flanders, offers a sort of laboratory conditions to study, design and plan fragments of open space in an urbanising context.
Allaert, Georges, Leinfelder, Hans
core   +1 more source