Results 51 to 60 of about 316,234 (316)

Framework for collaborative local climate adaptation scenario development- nexus between climate resilience, public health service and spatial planning [PDF]

International Journal of Climate Change Strategies and Management
Purpose – The interaction between urban development and climate change significantly impacts local public health services. Unfortunately, cities and involved institutions often fail to prioritize and integrate spatial planning when dealing with these ...
Wiriya Puntub, Stefan Greiving, Joern Birkmann   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Strategic planning for sustainable spatial, landscape and tourism development in Serbia [PDF]

, 2010
The paper presents an overview of the expected role of spatial and environmental planning in coordination and integration with strategic planning for sustainable spatial/territorial, landscape and tourism development.
Marija Maksin, Sasa Milijic, Milijić Saša, Maksin Marija, Milijić, Saša, Maksin, Marija   +5 more
core   +1 more source

Between author’s dreams and client’s wishes

Actas de Arquitectura Religiosa Contemporánea
Contemporary praxis of church construction in the Serbian Orthodox Church (SOC) and the client-architect relationship are conditioned by Church tradition and regulations.
Božidar Mani´c , Ana Nikovi´c, Boško Josimovi´c   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Co-Production in the Urban Setting: Fostering Definitional and Conceptual Clarity Through Comparative Research

Urban Planning
Co-production is a concept which is increasingly popular in the planning field to refer to multi-stakeholder collaboration and partnership with citizens.
Dahae Lee, Patricia Feiertag, Lena Unger
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Spatial Planning and Transformations in the Spatial Structure of Zagreb

Dela, 2016
Paper discusses the characteristics of the urban development of the City Zagreb by analysing the development of spatial planning and the changed power relations. During the last 20 years, the transformations have been mainly negative and have had important impact on changing the structure of residential, commercial and business zones, and on conversion
Njegač, Dražen, Pintarić, Tomislav, Prelogović, Vedran   +2 more
openaire   +4 more sources

Spatial Knowledge and Urban Planning

Urban Planning, 2022
Urban planning is simultaneously shaped by and creates new (spatial) knowledge. The changes in planning culture that have taken place in the last decades—especially the so-called communicative turn in planning in the 1990s—have brought about an increased attention to a growing range of stakeholders of urban development, their interests, logics, and ...
Anna Juliane Heinrich, Angela Million, Karsten Zimmermann   +2 more
openaire   +3 more sources