Results 51 to 60 of about 5,498,099 (308)

Strategic planning for sustainable spatial, landscape and tourism development in Serbia [PDF]

open access: yes, 2010
The paper presents an overview of the expected role of spatial and environmental planning in coordination and integration with strategic planning for sustainable spatial/territorial, landscape and tourism development.
Marija Maksin   +5 more
core   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Understanding Europeanisation from Within - The Interpretation, Implementation and Instrumentalisation of European Spatial Planning in Austria and Finland

open access: yes, 2018
Despite more than two decades of debate about European planning policies, the ways in which the European Union affects urban and regional planning in its member states remain ambiguous.
Purkarthofer, Eva, Eva Purkarthofer
core   +1 more source

The implementation model of planning rules in spatial plans [PDF]

open access: yes, 2015
The implementation of spatial plans in past practice in Serbia was the weakest link of planning - theoretically insufficiently studied, methodologically vague and non-positioned, and only formally and partially carried out in practice. There is a general
Stefanović, Nebojša   +2 more
core   +1 more source

Do objective neighbourhood characteristics relate to residents’ preferences for certain sports locations? A cross-sectional study using a discrete choice modelling approach

open access: yesBMC Public Health, 2017
Background The number of sports facilities, sports clubs, or city parks in a residential neighbourhood may affect the likelihood that people participate in sports and their preferences for a certain sports location.
Ineke Deelen   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

Mobilising Situated Local Knowledge for Participatory Urban Planning Through Storytelling

open access: yesUrban Planning, 2022
Participatory urban planning does not take place outside of social systems of privilege and discrimination; likewise, the negotiation of knowledge claims in planning processes is embedded in social relations defined by “gender,” “race,” and “class.” In ...
Hanna Seydel, Sandra Huning
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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