Results 51 to 60 of about 19,086 (267)
Location Prediction Based on Transition Probability Matrices Constructing from Sequential Rules for Spatial-Temporal K-Anonymity Dataset. [PDF]
PLoS ONE, 2016 Spatial-temporal k-anonymity has become a mainstream approach among techniques for protection of users' privacy in location-based services (LBS) applications, and has been applied to several variants such as LBS snapshot queries and continuous queries ...
Haitao Zhang +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Genomes as geography: using GIS technology to build interactive genome feature maps
BMC Bioinformatics, 2006 Background Many commonly used genome browsers display sequence annotations and related attributes as horizontal data tracks that can be toggled on and off according to user preferences.
Beard M Kate +3 more
doaj +1 more source
Top-k Spatial Preference Queries [PDF]
2007 IEEE 23rd International Conference on Data Engineering, 2007 A spatial preference query ranks objects based on the qualities of features in their spatial neighborhood. For example, consider a real estate agency office that holds a database with available flats for lease. A customer may want to rank the flats with respect to the appropriateness of their location, defined after aggregating the qualities of other ...
Man Lung Yiu +3 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Spatial queries with two kNN predicates [PDF]
Proceedings of the VLDB Endowment, 2012 The widespread use of location-aware devices has led to countless location-based services in which a user query can be arbitrarily complex, i.e., one that embeds multiple spatial selection and join predicates. Amongst these predicates, the k -Nearest-Neighbor ( k NN) predicate stands as one ...
Aly, Ahmed +2 more
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Can internet search queries be used for dengue fever surveillance in China?
International Journal of Infectious Diseases, 2017 China experienced an unprecedented outbreak of dengue fever in 2014, and the number of cases reached the highest level over the past 25 years. Traditional sentinel surveillance systems of dengue fever in China have an obvious drawback that the average ...
Pi Guo +7 more
doaj +1 more source
LocationSpark: In-memory Distributed Spatial Query Processing and Optimization
Frontiers in Big Data, 2020 Due to the ubiquity of spatial data applications and the large amounts of spatial data that these applications generate and process, there is a pressing need for scalable spatial query processing.
Mingjie Tang +5 more
doaj +1 more source