Results 91 to 100 of about 3,471,337 (333)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Method for Generation of Indoor GIS Models Based on BIM Models to Support Adjacent Analysis of Indoor Spaces

ISPRS International Journal of Geo-Information, 2020
Methods for the generation of indoor geographic information system (GIS) models based on building information modelling (BIM) models can promote the analysis and application of indoor GIS, avoiding the complexity of traditional indoor space collection ...
Qingxiang Chen, Jing Chen, Wumeng Huang
doaj   +1 more source

Hu-Fu: efficient and secure spatial queries over data federation

The VLDB journal
Data isolation has become an obstacle to scale up query processing over big data, since sharing raw data among data owners is often prohibitive due to security concerns. A promising solution is to perform secure queries over a federation of multiple data
Yongxin Tong, Yuxiang Zeng, Yang Song, Xuchen Pan, Zeheng Fan, C. Xue, Zimu Zhou, Xiaofei Zhang, Lei Chen, Yi Xu, Ke Xu, Weifeng Lv   +11 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A words-of-interest model of sketch representation for image retrieval [PDF]

, 2011
In this paper we propose a method for sketch-based image retrieval. Sketch is a magical medium which is capable of conveying semantic messages for user. It’s in accordance with user’s cognitive psychology to retrieve images with sketch.
Guo, Wen-Jin, Liu, Yong-Jin, Luo, Xi, Ma, Cui-Xia, Song, Dawei   +4 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

An intelligent user interface for browsing satellite data catalogs [PDF]

A large scale domain-independent spatial data management expert system that serves as a front-end to databases containing spatial data is described. This system is unique for two reasons. First, it uses spatial search techniques to generate a list of all
Cromp, Robert F., Crook, Sharon
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Gridvoronoi: An Efficient Spatial Index for Nearest Neighbor Query Processing

IEEE Access, 2019
In this paper, based upon Voronoi Diagram, we propose GridVoronoi which is a novel spatial index that enables users to find the spatial nearest neighbour (NN) from two-dimensional (2D) datasets in almost O(1) time.
Chongsheng Zhang, George Almpanidis, Faegheh Hasibi, Gaojuan Fan   +3 more
doaj   +1 more source