Results 71 to 80 of about 38,593 (265)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

GP-Tree: An in-memory spatial index combining adaptive grid cells with a prefix tree for efficient spatial querying

Big Earth Data
Efficient spatial indexing is crucial for processing large-scale spatial data. Traditional spatial indexes, such as STR-Tree and Quad-Tree, organize spatial objects based on coarse approximations, most commonly their minimum bounding rectangles (MBRs ...
Xiangyang Yang, Xuefeng Guan, Lanxue Dang, Yi Xie, Qingyang Xu, Huayi Wu, Jiayao Wang   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Prototype as query for few shot semantic segmentation

Complex & Intelligent Systems
Few-shot Semantic Segmentation (FSS) was proposed to segment unseen classes in a query image, referring to only a few annotated examples named support images. One of the characteristics of FSS is spatial inconsistency between query and support targets, e.
Leilei Cao, Yibo Guo, Ye Yuan, Qiangguo Jin   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Gridvoronoi: An Efficient Spatial Index for Nearest Neighbor Query Processing

IEEE Access, 2019
In this paper, based upon Voronoi Diagram, we propose GridVoronoi which is a novel spatial index that enables users to find the spatial nearest neighbour (NN) from two-dimensional (2D) datasets in almost O(1) time.
Chongsheng Zhang, George Almpanidis, Faegheh Hasibi, Gaojuan Fan   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Improving NoSQL Storage Schema Based on Z-Curve for Spatial Vector Data

IEEE Access, 2019
NoSQL database can provide massive, high concurrency, and scalable services for storing different types of data. HBase, a type of NoSQL database, in which columns are grouped into column families, is very suitable for storing semi-structured or ...
Dongfang Zhang, Yong Wang, Zhenling Liu, Shijie Dai   +3 more
doaj   +1 more source

Spatial Queries in the Presence of Obstacles

, 2004
Despite the existence of obstacles in many database applications, traditional spatial query processing utilizes the Euclidean distance metric assuming that points in space are directly reachable. In this paper, we study spatial queries in the presence of obstacles, where the obstructed distance between two points is defined as the length of the ...
Jun Zhang 0005, Dimitris Papadias, Kyriakos Mouratidis, Manli Zhu   +3 more
openaire   +3 more sources