Results 51 to 60 of about 38,593 (265)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Top-k Spatial Preference Queries [PDF]
2007 IEEE 23rd International Conference on Data Engineering, 2007 A spatial preference query ranks objects based on the qualities of features in their spatial neighborhood. For example, consider a real estate agency office that holds a database with available flats for lease. A customer may want to rank the flats with respect to the appropriateness of their location, defined after aggregating the qualities of other ...
Man Lung Yiu +3 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Spatial queries with two kNN predicates [PDF]
Proceedings of the VLDB Endowment, 2012 The widespread use of location-aware devices has led to countless location-based services in which a user query can be arbitrarily complex, i.e., one that embeds multiple spatial selection and join predicates. Amongst these predicates, the k -Nearest-Neighbor ( k NN) predicate stands as one ...
Aly, Ahmed +2 more
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Querying spatial data by dominators in neighborhood [PDF]
Information Systems, 2018 Spatial objects in reality are often associated with geographic locations (e.g., longitude and latitude) as well as multiple quality attributes. Quality attributes make it possible to compare spatial objects according to the dominance concept. Specifically, an object pi is said to dominate another object pj if pi is no worse than pj on all quality ...
Hua Lu 0001, Man Lung Yiu, Xike Xie
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
2DPR-Tree: Two-Dimensional Priority R-Tree Algorithm for Spatial Partitioning in SpatialHadoop
ISPRS International Journal of Geo-Information, 2018 Among spatial information applications, SpatialHadoop is one of the most important systems for researchers. Broad analyses prove that SpatialHadoop outperforms the traditional Hadoop in managing distinctive spatial information operations.
Ahmed Elashry +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
SGIR-Tree: Integrating R-Tree Spatial Indexing as Subgraphs in Graph Database Management Systems
ISPRS International Journal of Geo-InformationEfficient spatial query processing in Graph Database Management Systems (GDBMSs) has become increasingly important owing to the prevalence of spatial graph data.
Juyoung Kim +4 more
doaj +1 more source