Results 71 to 80 of about 3,471,337 (333)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ANALISA KECEPATAN SPATIAL QUERY DATA SATELIT PADA BEBERAPA STORAGE ENGINE MYSQL DATABASE

Matrix: Jurnal Manajemen Teknologi dan Informatika, 2016
Penerapan spatial database untuk data satellite remote sensing, membutuhkan struktur data yang memungkinkan proses spatial query dilakukan dengan kecepatan tinggi, oleh karena volume data satelit biasanya sangat besar.
I Ketut Swardika
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

GSA: node failures tolerent spatial window query processing algorithm in wireless sensor networks

Tongxin xuebao, 2008
A node failures tolerent spatial window query processing algorithm called GSA was proposed. The grid size parameter was studied and a grid-based data collection schedule scheme to avoid the message collisions in the process of data collection was ...
LIU Liang, QIN Xiao-lin, DAI Hua, SHEN Jia-jia   +3 more
doaj  

Efficient query processing on large spatial databases: A performance study

Journal of Systems and Software, 2017
A spatial index, called xBR+-tree, is compared against the R*-tree and the R+-tree.Performance of tree building and processing of common spatial queries is studied.Existing and new algorithms for processing these queries are utilized.Extensive ...
George Roumelis, M. Vassilakopoulos, Antonio Corral, Y. Manolopoulos   +3 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Top-K Collective Spatial Keyword Queries

IEEE Access, 2019
With the advent of a large number of spatial-textual data, collective spatial keyword queries have been widely studied in recent years. However, the collective spatial keyword query studied so far usually looks for only a set of objects. In addition, the
Danni Su, Xu Zhou, Zhibang Yang, Yifu Zeng, Yunjun Gao   +4 more
doaj   +1 more source

Efficient Collective Spatial Keyword Query Processing on Road Networks

IEEE transactions on intelligent transportation systems (Print), 2016
The collective spatial keyword query (CSKQ), an important variant of spatial keyword queries, aims to find a set of the objects that collectively cover users' queried keywords, and those objects are close to the query location and have small inter-object
Yunjun Gao, Jingwen Zhao, Baihua Zheng, Gang Chen   +3 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source