Results 141 to 150 of about 994,786 (316)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Decision map for spatial decision making in urban planning

, 2005
In this paper, we introduce the concept of decision map and illustrate the way this new concept can be used effectively to support participation in spatial decision making and in urban planning. First, we start by introducing our spatial decision process
Pusceddu, Clara, Roy, Bernard, Chakhar, Salem, Mousseau, Vincent   +3 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Multi-scale scenarios of spatial-temporal dynamics in the European livestock sector

, 2011
The European livestock sector has changed rapidly in the recent past and further changes are expected in the near future due to reforms in the European Common Agricultural Policy (CAP), increasing environmental concerns and changing consumer awareness ...
Berien Elbersen, Woltjer, G.B., Stehfest, E., Neumann, K., Woltjer, G.B, Peter H. Verburg, Kathleen Neumann, Verburg, P.H., Elbersen, B.S., Verburg, P.H.; id_orcid, Elke Stehfest, Elbersen, B., Geert B. Woltjer   +12 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The modifiable areal unit phenomenon: an investigation into the scale effect using UK census data

, 2008
The Modifiable Areal Unit Phenomenon (MAUP) has traditionally been regarded as a problem in the analysis of spatial data organised in areal units. However, the approach adopted here is that the MAUP provides an opportunity to gain information about the ...
Manley, D. J. (David John)
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Field-Scale Experimental Designs and Spatial Econometric Methods for Precision Farming: Strip-Trial Designs for Rice Production Decision Making

Site-specific data is spatially variable, precluding traditional econometric analysis. Some field-scale experimental designs present logistical, operational and mathematical problems in estimating treatment differences, specifically when adjacent ...
Florax, Raymond J.G.M., Griffin, Terry W., Lowenberg-DeBoer, James   +2 more
core  

Spatial variation in functional group diversity in a sandflat benthic community: implications for ecosystem resilience

, 2013
The resilience of macrobenthic communities to environmental stress depends upon the vulnerability, adaptability and connectivity of species. Recent studies suggest that the function(s) species perform may be more influential in driving community response
Greenfield, Barry Leon
core  

Smooth-car mixed models for spatial count data [PDF]

, 2008
Penalized splines (P-splines) and individual random effects are used for the analysis of spatial count data. P-splines are represented as mixed models to give a unified approach to the model estimation procedure.
Durbán, María, Lee, Dae-Jin
core