Results 121 to 130 of about 8,060,684 (303)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Geographical scale and the role of firm migration in spatial economic dynamics [PDF]
Spatial economic change can be decomposed in it's demographic constituents firm formation, closure, relocation and growth. This paper focusses on the role of relocation in the balancing equation of spatial economic dynamics: Total Change(zone i) = New ...
Veronique Schutjens, Leo JG Van Wissen
core
Temperature Variability on Coral Reefs Versus Gridded SST – The Long and the Short of It
Geochemistry, Geophysics, GeosystemsCoral‐based temperature reconstructions and gridded sea‐surface‐temperature (gSST) data sets both provide valuable insights into tropical climate variability.
A. M. Dolman, T. Laepple
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
The discrete dynamics of small-scale spatial events: agent-based models of mobility in carnivals and street parades [PDF]
, 2002 Small-scale spatial events are situations in which elements or objects vary in such away that temporal dynamics is intrinsic to their representation and explanation. Someof the clearest examples involve local movement from conventional traffic modelingto
DeSyllas, J, Batty, M, Huxbury, E
core
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Shuitu baochi yanjiu, 2009 Based on the image of SPOT5 in 2005,karst rocky desertification landscape patterns in Boluo area was classified as:no,latent,slight,moderate,strong,and extremely strong karst rocky desertification types.Furthermore,this paper discussed the relationship ...
LI Yang-bing1 +4 more
doaj
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Smooth-car mixed models for spatial count data [PDF]
, 2008 Penalized splines (P-splines) and individual random effects are used for the analysis of spatial count data. P-splines are represented as mixed models to give a unified approach to the model estimation procedure.
Durbán, María +2 more
core +1 more source