Results 61 to 70 of about 14,042 (259)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

Does Digital Technology Development Promote Entrepreneurial Activity? Evidence from Spatial Spillover Effects in China

Systems
This study examines how digital technology development affects entrepreneurial activity from a spatial perspective. Existing studies have mainly emphasized the local entrepreneurial effects of digital technology, while paying relatively limited attention
Jia Di, Chunhui Yuan, Xiaolong Li
doaj   +1 more source

Spatial spillover effects of sustainable development in the EU

Spatial Economic Analysis
This study analyses the impact of environmental policy stringency, hydropower consumption and oil consumption on the sustainable development index for 20 EU countries from 1996 to 2020. By incorporating a measure of strict environmental policies, this research aims to fill a critique gap in literature, becoming the first study to examine spillover ...
Çağla Bucak, Abdurrahman Nazif Çatık
openaire   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

High‐Density‐Cluster Ru Catalyst Substitute for Pt/C Benchmark Improves Membrane Water Electrolysis

Advanced Science, EarlyView.
Yuan et al. report a high‐density, monodispersed Ru cluster catalyst featuring interfacial covalent bonds that modulate the electronic structure and optimize intermediate adsorption–desorption, thereby conferring pH‐universal HER activity with ampere‐level current densities and enabling the development of Pt‐free membrane electrodes.
Zhen Yuan, Jia Xu, Zhongchen Gao, Linyan A, Shiying Guo, Jingguo Hu, Zhengshan Tian, Xiaoyong Xu   +7 more
wiley   +1 more source

Spatial spillover analysis of a cluster-randomized trial against dengue vectors in Trujillo, Venezuela.

PLoS Neglected Tropical Diseases, 2020
BackgroundThe ability of cluster-randomized trials to capture mass or indirect effects is one reason for their increasing use to test interventions against vector-borne diseases such as malaria and dengue.
Neal Alexander, Audrey Lenhart, Karim Anaya-Izquierdo   +2 more
doaj   +1 more source

Spatial Spillover Effects in the Labor Market in a Middle-Income Country

Spatial Economic Analysis
Most macroeconomic labor literature on estimating matching functions does not consider spatial spillover effects. However, job search and vacancy-filling processes often involve neighboring locations, as local workers can search for and fill vacancies in nearby labor markets.
Leonardo-Fabio Morales, Mauricio Quiñones, Eleonora Dávalos, Luis-Felipe Gaviria   +3 more
openaire   +1 more source

Modelling spillover effects in spatial stochastic frontier analysis [PDF]

, 2023
In the last two decades, authors have begun to expand classical stochastic frontier (SF) models in order to include also some spatial components. Indeed, firms tend to concentrate in clusters, taking advantage of positive agglomeration externalities due to cooperation, shared ideas and emulation, resulting in increased productivity levels.
openaire   +1 more source

Hybrid Semi‐Transparent Perovskite‐Photovoltaics and Concentrated Solar‐Thermal Harvesting Collectors

Advanced Science, EarlyView.
A hybrid semi‐transparent perovskite‐photovoltaic and concentrating solar‐thermal collector is developed to spectrally split sunlight for simultaneous electricity and heat generation. The design achieves thermal decoupling between the photovoltaic and thermal components, offering a promising route for efficient co‐harvesting of solar electricity and ...
Nada. A. Alati, Parth H. Arya, Yu Tian, Ashok Reddy, David B. Ritzer, Bahram Abdollahi Nejand, Ulrich W. Paetzold, Bryce S. Richards, Gan Huang   +8 more
wiley   +1 more source