Results 171 to 180 of about 387,386 (299)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Harnessing the potential of spatial statistics for spatial omics data with pasta. [PDF]

Nucleic Acids Res
Emons M, Gunz S, Crowell HL, Mallona I, Kuehl M, Furrer R, Robinson MD.   +6 more
europepmc   +1 more source

Application of data harmonization and tract-based spatial statistics reveals white matter structural abnormalities in pediatric patients with focal cortical dysplasia. [PDF]

Epilepsy Behav, 2023
Chu DY, Adluru N, Nair VA, Adluru A, Choi T, Kessler-Jones A, Dabbs K, Hou J, Hermann B, Prabhakaran V, Ahmed R.   +10 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Resting-state spatial statistics of NK cell receptors may improve early signal discrimination. [PDF]

Biophys J
Ahmad S, Mukhopadhyay D, Grewal RK, Jayaprakash C, Das J.   +4 more
europepmc   +1 more source

Spatial statistics is a comprehensive tool for quantifying cell neighbor relationships and biological processes via tissue image analysis. [PDF]

Cell Rep Methods, 2022
Summers HD, Wills JW, Rees P.
europepmc   +1 more source

Providing scientific visualisation for spatial data analysis: criteria and an assessment of SAGE [PDF]

A consistent theme in recent work on developing exploratory spatial data analysis (ESDA) has been the importance attached to visualization techniques, particularly following the pioneering development of packages such as REGARD by Haslett et al (1990 ...
Robert Haining, Stephen Wise, Paola Signoretta   +2 more
core  

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Gray matter microstructural alterations and their correlation with systemic biomarkers in hepatic encephalopathy: a NODDI study using gray-matter based spatial statistics. [PDF]

Front Neurol
Xie F, Wang X, Zhang H, Wang J, Wang S, Cheng P, Zhou J, Zhan H.   +7 more
europepmc   +1 more source

Brain regions associated with Brunnstrom and functional independence measure scores in patients after a stroke: a tract-based spatial statistics study. [PDF]

J Phys Ther Sci, 2023
Uchiyama Y, Domen K, Koyama T.
europepmc   +1 more source