Results 31 to 40 of about 4,261,904 (264)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Integrating Point Process Models, Evolutionary Ecology and Traditional Knowledge Improves Landscape Archaeology—A Case from Southwest Madagascar

open access: yesGeosciences, 2020
Landscape archaeology has a long history of using predictive models to improve our knowledge of extant archaeological features around the world. Important advancements in spatial statistics, however, have been slow to enter archaeological predictive ...
Dylan S. Davis   +2 more
doaj   +1 more source

A Simple Spatial Method for Identifying Point Clusters by Neighbourhood Relationships

open access: yesEcologies, 2021
Point events can be distributed regularly, randomly, or in clusters. A cluster of points is defined by the distance from which any point included in a cluster is farther from any other point outside the cluster. Many solutions and methods are possible to
Neftalí Sillero
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Spatial variability of groundwater recharge - II. Factors affecting variability and taking account of it in estimating recharge [PDF]

open access: yes, 2004
The accompanying paper provided evidence to suggest that spatial variability of groundwater recharge is ‘true’ variability. This paper attempts to determine the major causes of such variability even at small distances, if there appear to be a frequency ...
De Silva, RP
core  

Spatial Scan Statistics Adjusted for Multiple Clusters

open access: yesJournal of Probability and Statistics, 2010
The spatial scan statistic is one of the main epidemiological tools to test for the presence of disease clusters in a geographical region. While the statistical significance of the most likely cluster is correctly assessed using the model assumptions ...
Zhenkui Zhang   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Spatial scan statistics for matched case-control data.

open access: yesPLoS ONE, 2019
Spatial scan statistics are widely used for cluster detection analysis in geographical disease surveillance. While this method has been developed for various types of data such as binary, count, and continuous data, spatial scan statistics for matched ...
Inkyung Jung
doaj   +1 more source

Temporal and Spatial Evolution Analysis of Earthquake Events in California and Nevada Based on Spatial Statistics

open access: yesISPRS International Journal of Geo-Information, 2021
Studying the temporal and spatial evolution trends in earthquakes in an area is beneficial for determining the earthquake risk of the area so that local governments can make the correct decisions for disaster prevention and reduction.
Weifeng Shan   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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