Results 101 to 110 of about 17,807,427 (330)
DSSR: an integrated software tool for dissecting the spatial structure of RNA
Nucleic Acids Research, 2015 Insight into the three-dimensional architecture of RNA is essential for understanding its cellular functions. However, even the classic transfer RNA structure contains features that are overlooked by existing bioinformatics tools.
Xiang-Jun Lu, H. Bussemaker, W. Olson
semanticscholar +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Clinical and Translational MedicineIntra‐tumour immune infiltration is a crucial determinant affecting immunotherapy response in non‐small cell lung cancer (NSCLC). However, its phenotype and related spatial structure have remained elusive.
Guangyu Fan +5 more
doaj +1 more source
On proximity and hierarchy : exploring and modelling space using multilevel modelling and spatial econometrics [PDF]
, 2009 Spatial econometrics and also multilevel modelling techniques are increasingly part of the regional scientists‟ toolbox. Both approaches are used to model spatial autocorrelation in a wide variety of applications. However, it is not always clear on which
Parenti, Angela, Vanoutrive, Thomas
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Urban Environmental Health: From Urban Spatial Structure to Citizen Participation (Case Study: Tehran Municipality District 1) [PDF]
توسعه پایدار شهری, 2021 Achieving a healthy urban environment is one of the goals of sustainable urban development. Urban environmental health is influenced by the condition and spatial structure. In addition, the human factor as the social environment issue plays a significant
Jila Sajjadi +2 more
doaj
American Naturalist, 2015 In recent years, ecologists have stepped up to address the challenges imposed by rapidly changing climates. Some researchers have developed niche-based methods to predict how species will shift their ranges.
M. Sears, M. Angilletta
semanticscholar +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Interpreting interpolation: the pattern of interpolation errors in digital surface models derived from laser scanning data [PDF]
, 2003 Errors within height models have, in the past, been communicated in terms of global measures ofaccuracy for the model. Such quantification ignores the spatial structure of errors across thesurface, hindering subsequent analysis.
Holland, D, Longley, PA, Smith, SL
core
, 2010 Complex systems are very often organized under the form of networks where nodes and edges are embedded in space. Transportation and mobility networks, Internet, mobile phone networks, power grids, social and contact networks, neural networks, are all ...
Barthelemy, Marc
core +2 more sources