Results 71 to 80 of about 3,119,517 (283)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Spatial variability of soil nitrogen forms and the activity of N-cycle enzymes
Plant, Soil and Environment, 2016 Knowledge about the spatio-temporal variability of soil chemical and biological properties is crucial in evaluating their structure-function relationship and their impact on ecosystem functions.
J. Długosz, A. Piotrowska-Długosz
doaj +1 more source
Analysis The Pattern of Physical and Spatial Development by Holdern Model Case Staudy: Gonabad City [PDF]
جغرافیا و آمایش شهری منطقهای, 2016 The cities, during their life will change and develop due to different factors, but a good city is a city which its physic provides the requirements of its residents with respect to the time changes. Uncontrolled expansion and development of urban areas
dr. bakhtiyar ezat panah +1 more
doaj +1 more source
Automatic Reconstruction of Fault Networks from Seismicity Catalogs: 3D Optimal Anisotropic Dynamic Clustering [PDF]
, 2007 We propose a new pattern recognition method that is able to reconstruct the 3D structure of the active part of a fault network using the spatial location of earthquakes.
Bhattacharya +36 more
core +3 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Spatial structure research by analysing land prices
Modern Geográfia, 2019 During the period of planned economy, without the forces of market economy, land prices were not taken into consideration as the factors of settlement development appropriate to their significance.
Tánczos-Szabó, László
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The village and the city: a diagnostic study of the spatial embedding patterns in villages absorbed by cities in Bahrain [PDF]
, 2009 During the growth of cities villages are frequently absorbed into the fabric of that conurbation. But what are the consequences of this? To what extent and how well do these villages become part of the overall fabric of the city?
AL-Ghatam, W.
core