Results 71 to 80 of about 19,178,163 (215)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Tether

open access: yes, 2019
Research Background: The group exhibition Tether interconnects the diverse art practices of Griffith University arts researchers through underlying themes and approaches. The participating artists, Mulder, Giles, Anderson, Wareham, and Wellisch, aimed to
Anderson, Adam   +4 more
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Electric Sail Tether Deployment System for CubeSats [PDF]

open access: yes, 2019
An Electric Sail (E-Sail) propulsion system consists of long, thin tethers - positively-charged wires extending radially and symmetrically outward from a spacecraft.
Hunter, John Davis   +6 more
core  

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

open access: yesAdvanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li   +8 more
wiley   +1 more source

Electrodynamic tether [PDF]

open access: yes, 1985
The electrodynamic tether consists of a satellite deployed to a distance of 20 km by an electrically conducting tether. The space station hardware consists of a 12 meter deployment boom, satellite cradle, tether reel and motor, and other tether support ...
Roberts, W. T.
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Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

open access: yesAdvanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang   +10 more
wiley   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

open access: yesAdvanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu   +13 more
wiley   +1 more source

Mathematical modeling of the deployment of the orbital tether system [PDF]

open access: yes, 2006
: The well-known mathematical model of an orbital tether system treats the tether as a set of mass points that are connected in series by weightless non-stretched threads. This model is described by ordinary differential equations and allows to
Sazonov V. V. http://library.keldysh.ru/author_page.asp?aid=1104
core  

Drop‐Location‐Insensitive Droplet‐Based Electricity Generator Using Polydimethylsiloxane Slippery Covalently Attached Liquid Coatings

open access: yesAdvanced Science, EarlyView.
Drop‐location sensitivity remains a key barrier to practical droplet‐based electricity generators (DEGs). Here, a polydimethylsiloxane slippery covalently attached liquid (PDMS‐SCAL)‐coated interface promotes droplet sliding instead of splitting or bouncing, allowing stable electricity generation from randomly falling raindrops. The resulting PDMS‐SCAL‐
Jung Bin Yang   +6 more
wiley   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

open access: yesAdvanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng   +9 more
wiley   +1 more source

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