Results 41 to 50 of about 68,356 (275)

Automation of Spatial Transcriptomics library preparation to enable rapid and robust insights into spatial organization of tissues

BMC Genomics, 2020
Background Interest in studying the spatial distribution of gene expression in tissues is rapidly increasing. Spatial Transcriptomics is a novel sequencing-based technology that generates high-throughput information on the distribution, heterogeneity and
Emelie Berglund, Sami Saarenpää, Anders Jemt, Joel Gruselius, Ludvig Larsson, Ludvig Bergenstråhle, Joakim Lundeberg, Stefania Giacomello   +7 more
doaj   +1 more source

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. [PDF]

, 2019
MotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy.
Agard, Bruno, Aghaeepour, Nima, Ando, Kazuo, Angst, Martin S, Callahan, Benjamin, Contrepois, Kévin, Culos, Anthony, Darmstadt, Gary L, DiGiulio, Daniel B, Druzin, Maurice L, Ganio, Edward, Gaudilliere, Brice, Gaudilliere, Dyani, Ghaemi, Mohammad Sajjad, Gibbs, Ronald, Han, Xiaoyuan, Lee-McMullen, Brittany, Lehallier, Benoit, Lewis, David B, Maric, Ivana, Mcilwain, David, McNeil, Leslie, Ngo, Thuy TM, Nolan, Garry, Partovi Nia, Vahid, Quaintance, Cecele, Quake, Stephen R, Relman, David A, Robaczewska, Anna, Rosenberg-Hasson, Yael, Shaw, Gary M, Sirota, Marina, Snyder, Michael P, Stanley, Natalie, Stevenson, David K, Tanada, Athena, Tibshirani, Robert, Tingle, Martha, Tsai, Amy, Winn, Virginia D, Wise, Paul, Wong, Ronald J, Wyss-Coray, Tony   +42 more
core   +3 more sources

Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics. [PDF]

, 2020
Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing.
Cang, Zixuan, Cinco, Rachel, Dai, Xing, Dragan, Morgan, Gong, Yanwen, Gratton, Enrico, Haensel, Daniel, Jin, Suoqin, Kessenbrock, Kai, MacLean, Adam L, Nguyen, Quy, Nie, Qing, Sun, Peng, Vu, Remy   +13 more
core   +2 more sources

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. [PDF]

, 2017
Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during ...
Ao, Yan, Burda, Josh, Farkhondeh, Vista, Itoh, Noriko, Itoh, Yuichiro, Johnsonbaugh, Hadley, Kaito, Max, Ohno, Ai, Ren, Emily, Sofroniew, Michael V, Tassoni, Alessia, Voskuhl, Rhonda R   +11 more
core   +2 more sources

Advances in spatial transcriptomics and its applications in cancer research

Molecular Cancer
Malignant tumors have increasing morbidity and high mortality, and their occurrence and development is a complicate process. The development of sequencing technologies enabled us to gain a better understanding of the underlying genetic and molecular ...
Yang Jin, Yuanli Zuo, Gang Li, Wenrong Liu, Yitong Pan, Ting Fan, Xin Fu, Xiaojun Yao, Yong Peng   +8 more
doaj   +1 more source

SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics

Genome Biology, 2023
AbstractSpatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to reproduce, or unrealistic.
Zhu, Jiaqiang, Shang, Lulu, Zhou, Xiang
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Gene clusters reflecting macrodomain structure respond to nucleoid perturbations

, 2010
Focusing on the DNA-bridging nucleoid proteins Fis and H-NS, and integrating several independent experimental and bioinformatic data sources, we investigate the links between chromosomal spatial organization and global transcriptional regulation.
Alberts, Ashburner, Babu, Ball, Beloin, Berger, Bertin, Bianca Sclavi, Blot, Boccard, Bradley, Bruno Bassetti, Cabrera, Cabrera, Cases, Chilcott, Cho, Cho, Cook, Cunha, Cunha, Dame, Darling, Dillon, Dorman, Duan, Eisen, Esnault, Espéli, Espéli, Fang, Gama-Castro, Grainger, Hengen, Hengge, Janga, Jeong, Jin, Junier, Kahramanoglou, Kalir, Kalir, Kelly, Keseler, Ko, Korea, Krin, Képès, Képès, Lang, Liu, Luijsterburg, Marco Cosentino Lagomarsino, Marr, Mathelier, Mercier, Moulin, Muskhelishvili, Nielsen, Oberto, Ogasawara, Oshima, Pesavento, Peter, Postow, Prigent-Combaret, Prüss, Reyes-Lamothe, Rocha, Saldana, Serres, Smith, Sonnenschein, Soutourina, Soutourina, Soutourina, Travers, Valens, Vittore F. Scolari, Vora, Wade, Wang, Wang, Wang, Warren, Weber, Wiggins, Wright, Zechiedrich, Zimmerman   +89 more
core   +2 more sources

Evidence of neutral transcriptome evolution in plants [PDF]

, 2008
The transcriptome of an organism is its set of gene transcripts (mRNAs) at a defined spatial and temporal locus. Because gene expression is affected markedly by environmental and developmental perturbations, it is widely assumed that transcriptome ...
Bailey, Beilstein, Brady, Broadley, Ceplitis, Craigon, Felsenstein, Filatov, Gilad, Gould, Graham, H. C. Bowen, Hammond, Hammond, Hampton, Hawes, J. P. Hammond, J. W. McNicol, Johnston, Khaitovich, Khaitovich, Khaitovich, Kimura, Koch, M. R. Broadley, N. S. Graham, Narsai, P. J. White, P. P. M. Iannetta, R. G. Fray, S. T. May, Schmid, Schranz, Soltis, Z. F. Emmerson   +34 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source