Results 51 to 60 of about 45,113 (260)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Graph attention automatic encoder based on contrastive learning for domain recognition of spatial transcriptomics

Communications Biology
Spatial transcriptomics is an emerging technology that enables the profiling of gene expression in tissues while preserving spatial location information.
Tianqi Wang, Huitong Zhu, Yunlan Zhou, Weihong Ding, Weichao Ding, Liangxiu Han, Xueqin Zhang   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Molecular landscape of the mouse adrenal gland and adjacent adipose tissue by spatial transcriptomics

Folia Histochemica et Cytobiologica
INTRODUCTION: . The adrenal glands are central regulators of endocrine homeostasis and stress adaptation. Despite decades of research, the molecular mechanisms governing adrenal zonation and cortical renewal remain incompletely understood.
Malgorzata Blatkiewicz, Szymon Hryhorowicz, Marta Szyszka, Joanna Suszynska-Zajczyk, Andrzej Plawski, Adam Plewinski, Andrea Porzionato, Ludwik K. Malendowicz, Marcin Rucinski   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Integrating multiple spatial transcriptomics data using community-enhanced graph contrastive learning.

PLoS Computational Biology
Due to the rapid development of spatial sequencing technologies, large amounts of spatial transcriptomic datasets have been generated across various technological platforms or different biological conditions (e.g., control vs. treatment).
Wenqian Tu, Lihua Zhang
doaj   +1 more source

Spatial transcriptomics in breast cancer: providing insight into tumor heterogeneity and promoting individualized therapy

Frontiers in Immunology
A comprehensive understanding of tumor heterogeneity, tumor microenvironment and the mechanisms of drug resistance is fundamental to advancing breast cancer research. While single-cell RNA sequencing has resolved the issue of “temporal dynamic expression”
Junsha An, Junsha An, Junsha An, Yajie Lu, Yuxi Chen, Yuling Chen, Zhaokai Zhou, Jianping Chen, Cheng Peng, Ruizhen Huang, Fu Peng, Fu Peng   +11 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics. [PDF]

Adv Sci (Weinh)
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods.
Cao H, Liu G, Xia J, Chen R, Wang T, Yang X, Fang R, Luo Y, Zeng P, Yu H, Zhang Y, Cui Y.   +11 more
europepmc   +3 more sources

Spatial transcriptomics levels up [PDF]

Nature Methods, 2019
An improved sequential fluorescence in situ hybridization approach allows one to image the expression of 10,000 genes in single cells.
openaire   +2 more sources