Results 41 to 50 of about 3,005 (218)
A espacialidade na construção da identidade
Cadernos EBAPE.BREste artigo tem o objetivo de propor a introdução, tanto conceitual quanto analítica, da dimensão espacial (ou espacialidade) nos estudos sobre identidade no processo organizativo.
Thiago Duarte Pimentel +1 more
doaj +1 more source
Terra Brasilis, 2013 The article applies to international geographical congresses, which have been held since 1871, a method of analysis centred upon the spatial inscription of knowledges.
Marie-Claire Robic
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A nova configuração do poder global
Caderno CRHHegemonia e império são termos diferentes, que oferecem interpretações profundamente distintas do poder estadunidense e suas manifestações contemporâneas, e de como dito poder pode ser mudado. Depois de uma breve introdução sobre ambos os termos, o texto
John Agnew
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Les sans-abris des quais d’Austerlitz
EchoGéo, 2008 The homeless' spatial practices are not well-known: that's why we tried, relying on several interviews, to study their spatiality which is similar to a perpetual fight. Forced to move by frequent explusions, yet their way of life is sedentary.
Emmanuel Fillon +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Gestalt Theory, 2020 The paper argues that all emotions possess a spatial and objective, social character. We can gain access to them only insofar as we are affected by them in a felt-bodily way.
Landweer Hilge
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source