Results 111 to 120 of about 9,112 (298)
Revista Ambiente & Água, 2012 The reference evapotranspiration is an important hydrometeorological variable; its measurement is scarce in large portions of the Brazilian territory, what demands the search for alternative methods and techniques for its quantification.
Silvio Jorge Coelho Simões +2 more
doaj +1 more source
Processes of Spatialization in the Americas [PDF]
, 2018 Where do the Americas begin, and where do they end? What is the relationship between the spatial constructions of «area» and «continent»? How were the Americas imagined by different actors in different historical periods, and how were these imaginations –
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Jurnal Komunikasi IndonesiaIn the era of local government autonomy and decentralization, numerous collaborations have emerged between local governments and local media, particularly in reporting government activities.
Awang Ruswandi
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Spatialization and Timbre for Effective Auditory Graphing [PDF]
, 2007 Spatialization (spatial separation) and timbre are the two salient auditory attributes facilitating a better comprehension of sonification (non-speech auditory display).While directional cues provide obvious interpretable structure for auditory display ...
Beilharz, KA, Song, H
core
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
ConfinsIn health studies, obtaining spatialized demographic data is essential for understanding diseases transmission and dispersal processes, and for calculating the incidence rate as well, which are fundamental to control and prevention strategies.
Leandro da Silva Gregorio +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source