Results 61 to 70 of about 2,736,580 (245)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identifying speaker from disguised speech using aural perception and Mel-frequency cepstral coefficient

Journal of Indian Speech Language & Hearing Association, 2015
Objective The present study intended to compare the accuracy of speaker identification using aural perception and semiautomatic method (Mel –Frequency Cepstral Coefficient; MFCC), when the speech is in disguise condition by using the handkerchief during ...
J. Praveena, Y. Krishna
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Improvement of Text Dependent Speaker Identification System Using Neuro-Genetic Hybrid Algorithm in Office Environmental Conditions [PDF]

, 2009
In this paper, an improved strategy for automated text dependent speaker identification system has been proposed in noisy environment. The identification process incorporates the Neuro-Genetic hybrid algorithm with cepstral based features.
Islam, Md. Rabiul, Rahman, Md. Fayzur
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Enhancing Speaker Recognition Models with Noise-Resilient Feature Optimization Strategies

Acoustics
This paper delves into an in-depth exploration of speaker recognition methodologies, with a primary focus on three pivotal approaches: feature-level fusion, dimension reduction employing principal component analysis (PCA) and independent component ...
Neha Chauhan, Tsuyoshi Isshiki, Dongju Li   +2 more
doaj   +1 more source

The Impact of Speaking Style on Speaker Classification Using Mel-Frequency Cepstral Coefficients [PDF]

زبان پژوهی
This research investigates the impact of different speaking styles (read and spontaneous) on speaker identification accuracy. Mel-Frequency Cepstral Coefficients (MFCCs) were employed as input features, and the Random Forest algorithm was used for ...
Homa Asadi
doaj   +1 more source

Speaker Identification using EEG

CoRR, 2020
In this paper we explore speaker identification using electroencephalography (EEG) signals. The performance of speaker identification systems degrades in presence of background noise, this paper demonstrates that EEG features can be used to enhance the performance of speaker identification systems operating in presence and absence of background noise ...
Gautam Krishna, Co Tran, Mason Carnahan, Ahmed H. Tewfik   +3 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source