Results 51 to 60 of about 2,081,168 (298)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Speaker Counting Based on a Novel Hive Shaped Nested Microphone Array by WPT and 2D Adaptive SRP Algorithms in Near-Field Scenarios

Sensors, 2023
Speech processing algorithms, especially sound source localization (SSL), speech enhancement, and speaker tracking are considered to be the main fields in this application. Most speech processing algorithms require knowing the number of speakers for real
Ali Dehghan Firoozabadi, Pablo Adasme, David Zabala-Blanco, Pablo Palacios Játiva, Cesar Azurdia-Meza   +4 more
doaj   +1 more source

Local spectral variability features for speaker verification [PDF]

Digital Signal Processing, 2016
Speaker verification techniques neglect the short-time variation in the feature space even though it contains speaker related attributes. We propose a simple method to capture and characterize this spectral variation through the eigenstructure of the sample covariance matrix. This covariance is computed using sliding window over spectral features.
Md. Sahidullah, Tomi Kinnunen
openaire   +3 more sources

Robust Speaker Localization Guided by Deep Learning-Based Time-Frequency Masking

IEEE/ACM Transactions on Audio Speech and Language Processing, 2019
Deep learning-based time-frequency (T-F) masking has dramatically advanced monaural (single-channel) speech separation and enhancement. This study investigates its potential for direction of arrival (DOA) estimation in noisy and reverberant environments.
Zhong-Qiu Wang, Xueliang Zhang, Deliang Wang   +2 more
semanticscholar   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Voice Interaction Recognition Design in Real-Life Scenario Mobile Robot Applications

Applied Sciences, 2023
This paper designed a voice interactive robot system that can conveniently execute assigned service tasks in real-life scenarios. It is equipped without a microphone where users can control the robot with spoken commands; the voice commands are then ...
Shih-An Li, Yu-Ying Liu, Yun-Chien Chen, Hsuan-Ming Feng, Pi-Kang Shen, Yu-Che Wu   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Localization of Speaker using Fusion Techniques and Neural Network Algorithms

Wasit Journal for Pure Sciences
ABSTACT Sound source localization especially speech and speaker is sole of the most significant techniques recently because used in various applications like smart environments, industry, robots, and audio conferences.
sawsan jaddoa, Rasha Ali, Mohammed Najm Abdullah, Buthainah F. Abed   +3 more
doaj   +1 more source

Cerebral Representation of Sound Localization Using Functional Near-Infrared Spectroscopy

Frontiers in Neuroscience, 2021
Sound localization is an essential part of auditory processing. However, the cortical representation of identifying the direction of sound sources presented in the sound field using functional near-infrared spectroscopy (fNIRS) is currently unknown ...
Xuexin Tian, Yimeng Liu, Zengzhi Guo, Jieqing Cai, Jie Tang, Jie Tang, Jie Tang, Jie Tang, Fei Chen, Hongzheng Zhang, Hongzheng Zhang   +10 more
doaj   +1 more source