Results 71 to 80 of about 5,042,936 (304)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
SPECIAL FORCES OFFICER INITIAL TRAINING REQUIREMENTS [PDF]
, 2020 What should institutional training teach to adequately prepare newly selected captains for service in Special Forces? This thesis looks holistically at what Special Forces officers need to know before arriving to a Special Forces group and makes ...
Coleman, David
core +2 more sources
Communications, 2005 The paper describes possibilities of the geographical information systems' usage in the pipe transport. All parts of information systems including hardware, software, peopleware, dataware and orgware are in a continuous process of development. Advantages
Juraj Sluka +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Resistance Operating Concept as a Tool for Increasing the Resilience of the State
Vojenské rozhledyThe article describes the issue of implementing the Resistance Operating Concept as part of a comprehensive approach to ensuring the defense of the state and its resilience.
Radek Dubec +2 more
doaj +1 more source
CONCLUSIONS ON HYBRID WARFARE [PDF]
Annals: Series on Military Sciences, 2019 A pioneer in the field of Public Relations, Edward L. Bernays, emphasized the use of words as weapons in his work entitled „Propaganda” in 1928. In „Public Relations”, he considered the word and image to be the representation of tools for building ...
Anghel ANDREESCU, Valentin DULGHERU
doaj
Special Operations Forces Truths — Cyber Truths
The Cyber Defense Review, 2016 The Special Operations Forces (SOF) Truths—humans are more important than hardware, quality is better than quantity, SOF cannot be mass produced,competent SOF cannot be created after emergencies occur, and most special operations require non-SOF ...
Stephen Fogarty, Jamie Nasi
doaj +1 more source
Technical Report. Bikini Scientific Resurvey. Report of the Technical Director. Volume 2
, 1947 Prepared for The Project Officer by the Technical Reports Section This report includes data and conclusions of the various Scientific Groups that worked in and about Bikini Atoll, at Rongerik Atoll, and at ...
Armed Forces Special Weapons Project (U.S.)
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source