Results 91 to 100 of about 7,303,155 (290)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
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Archives and Special Collections statement of potentially offensive or harmful historical language and/or ...
Archives and Special Collections
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Lietuvos Matematikos Rinkinys, 2011 A. Naftalevičius life review. Scientific work. Bibliographical listing.
Henrikas Jasiūnas, Vitolda Verikaitė
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Fuzzy special logic functions and applications [PDF]
, 1992 In this thesis, four special logic functions (threshold functions, monotone increasing functions, monotone decreasing functions, and unate functions) are extended to more general functions which allows the activities of these special functions to be a ...
Chou, Te-Shun
core +1 more source
Operational Solution of Non-Integer Ordinary and Evolution-Type Partial Differential Equations
Axioms, 2016 A method for the solution of linear differential equations (DE) of non-integer order and of partial differential equations (PDE) by means of inverse differential operators is proposed.
Konstantin V. Zhukovsky +1 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012 Two special functions, concerning Mittag-Leffler type functions, are studied. The first is the modification of generalized Mittag-Leffler function, which was introduced by A. Kilbas and M. Saigo; the second is the special case of the first one. The relation
Eugeniy N Ogorodnikov
doaj