Results 71 to 80 of about 3,673,223 (260)

Generalized Erdélyi-Kober Fractional Integrals and Images of Special Functions

open access: yesFractal and Fractional
The Riemann-Liuoville fractional integrals are the simplest and most popular operators of the classical fractional calculus. But their variants, the Erdélyi-Kober operators of fractional integration, have many more applications due to the freedom to ...
Virginia Kiryakova   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Singular Isotonic Oscillator, Supersymmetry and Superintegrability

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2012
In the case of a one-dimensional nonsingular Hamiltonian H and a singular supersymmetric partner H_a, the Darboux and factorization relations of supersymmetric quantum mechanics can be only formal relations.
Ian Marquette
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Enhancing Stability in Fractional-Order Systems: Criteria and Applications

open access: yesFractal and Fractional
This study investigates the stability of fractional-order systems with infinite delay, which are prevalent in many fields due to their effectiveness in modeling complex dynamic behaviors.
Safoura Rezaei Aderyani   +3 more
doaj   +1 more source

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