Results 51 to 60 of about 16,340,595 (288)
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
In June 1987 Council approved the establishment of Special Interest Groups.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Partial differential equations (PDEs) have long been used to describe and solve problems in fluid dynamics. The advent of Artificial Neural Networks (ANNs) has revolutionized the ways of tackling many problems, including the landscape of scientific ...
Danang A. Pratama +3 more
doaj +1 more source
Maximal Injective Real W∗-Subalgebras of Tensor Products of Real W∗-Algebras
It is known that injective (complex or real) W∗-algebras with particular factors have been studied well enough. In the arbitrary cases, i.e., in noninjective case, to investigate (up to isomorphism) W∗-algebras is hard enough, in particular, there exist ...
A. A. Rakhimov +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mass media and special interest groups [PDF]
Media revenues are an important determinant of media behavior. It is generally accepted that news coverage depends not only on the preferences of media consumers but also on the preferences of advertisers or subsidizing groups. However, existing models reach the opposite conclusions about the relationship between the profitability of advertising and ...
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Higher-order fuzzy sets have emerged as effective tools for decision-making under uncertainty. Among these, the circular intuitionistic fuzzy set (CIFS) has recently been introduced to better represent uncertain information.
Nuraini Rahim +3 more
doaj +1 more source

