Results 71 to 80 of about 16,340,595 (288)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Turning precision medicine into reality with statistics and data-driven decision making across pharmaceutical development

Communications Medicine
Ten years after the launch of the Precision Medicine Initiative, its broader impact remains uncertain beyond select genetic and oncological cases. Here, we share our perspective as pharmaceutical statisticians and propose strategic shifts to realize its ...
Guillaume Desachy, Karl Köchert, Nicole Krämer, René Kubiak, Biomarkers European Special Interest Group   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in JapanAJOG Global Reports at a Glance

AJOG Global Reports
Background: Time-lapse technology (TLT) has emerged as a significant advancement in the field of assisted reproductive technology (ART), providing continuous observation of embryos.
Mitsutoshi Yamada, MD, PhD, Kenji Ezoe, PhD, Satoshi Ueno, PhD, Osamu Yoshino, MD, PhD, Toshifumi Takahashi, MD, PhD   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Defining social prescribing link worker practice in Europe: an international Delphi consensus study of core functions, training needs and implementation conditions

BMJ Open
Objective To develop expert consensus on best practice approaches to social prescribing (SP) in European primary care, with a focus on the roles, competencies and implementation conditions for social prescribing link workers (SPLWs).Design A three-round ...
Kerryn Husk, , Joyce Kenkre, Hans Thulesius, Krzysztof Buczkowski, Thomas Zimmermann, Sónia Dias, Donata Kurpas, Carolyn Wallace, Carmen Cabezas Peña, Margareta Kristenson, Josep Vidal-Alaball, Marcello Bertotti, Thomas Kloppe, Hendrik Napierala, Wolfram Herrmann, Ferdinando Petrazzuoli, Sian Brand, Miriam Dolan, Gindrovel Dumitra, Sinah Evers, David Halata, Jean-Pierre Jacquet, Katerina Javorska, Carmen Lopez Fando, Juan Manuel Mendive, Nataša Mrduljaš-Đujić, Andrea Neculau, Sara Paternoster, Erwin Rebhandl, Joanne Robins, Susanna Althini, Ludmila Bezdíčková, Joelle Bradly, Antoine Canton, Adriana-Lavinia Cioca, Julia Commenda, Josep Lluís de Peray, Angelina González-Viana, Paulo Guimarães, Sabrina Herzog, Jenny Irvine, Laura Mihaela Isop, Anita Jensen, Natálie Kerhartová, Bela Kolarš, Eva Kozub, Antje Liesener, Sanja Martic-Biocina, Serena Naim, Victoria Sullivan, Roxana Surugiu, Emanuele Torri, Amélie Wiegand   +53 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source