Results 61 to 70 of about 4,923,427 (296)

Coping with Poorly Understood Domains: the Example of Internet Trust [PDF]

open access: yes, 1998
The notion of trust, as required for secure operations over the Internet, is important for ascertaining the source of received messages. How can we measure the degree of trust in authenticating the source?
Basden, Andrew   +3 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Why Knowledge is Special

open access: yesPhilosophy, 2017
AbstractI argue against Greco's account of the value of knowledge, according to which knowledge is distinctively valuablevis-à-visthat which falls short of knowledge in virtue of its status as an achievement and achievements being finally valuable. Instead, I make the case that virtuous belief is also an achievement.
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Appearance and Content Assessment of Printed Books for the Age Groups A and B with Emphasis on Guilford's Creativity Components [PDF]

open access: yesکتابداری و اطلاع‌رسانی, 2019
Objective: The aim is to conduct appearance and content assessment of printed books for the age groups A and B, with emphasis on the components of Guilford creativity. These components consist of fluidity, flexibility, originality, and expansion. However,
Marzieh Karamizadeh Zavareh   +2 more
doaj   +1 more source

Collaboration among teachers in inclusive special education program classrooms [PDF]

open access: yes, 2016
Collaboration between teachers and special education teachers is a vital factor in ensuring the success of the implementation of the Inclusive Education Programs especially in the teaching and learning aspects.
A. Bakar, A.   +9 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

THE ROLE OF FORENSIC SPECIALISTS AS EXPERTS FOR THE DEFENSE

open access: yesТеория и практика судебной экспертизы, 2015
The paper analyzes perspectives from the professional communities of legalscientists and lawyers on the issues of authority and significance of forensicexperts and their special knowledge when they represent the side of the defense.The author offers his ...
S. Zhdanov
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Teacher Attitudes About Compensation Reform: Implications for Reform Implementation 2010 [PDF]

open access: yes, 2010
Examines teachers' views of merit pay and alternative compensation for those in hard-to-staff subject areas and schools and those with special knowledge and skills. Analyzes determining factors for varying levels of support.
Dan Goldhaber   +2 more
core  

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