Results 71 to 80 of about 11,433,067 (229)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Участие специалиста при проведении допроса

Проблеми Законності, 2016
Статья посвящена исследованию отдельных вопросов участия специалиста при проведении такого распространенного следственного (розыскного) действия, как допрос. Анализируются процессуальные нормы, регламентирующие участие специалиста в допросе.
Вікторія Олегівна Яремчук
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Notice_on_Potentially_Offensive_Historical_Language_and_Content_FINAL

Archives and Special Collections statement of potentially offensive or harmful historical language and/or ...
Archives and Special Collections
core   +1 more source

THE CONCEPT OF THE CRIMINALISTIC DOCTRINE OF SPECIAL KNOWLEDGE USED IN THE INVESTIGATION OF CRIMES INVOLVING MINORS

Правовое государство: теория и практика
The article reveals the prerequisites for the formation of the criminalistic doctrine of special knowledge used in the investigation of crimes involving minors.
KHALIULLINA Aigul Faatovna
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

SOME ASPECTS OF THE CRIMINALISTIC ASSESSMENT OF THE RELIABILITY OF EVIDENCE OBTAINED USING SPECIAL KNOWLEDGE IN THE INVESTIGATION OF CRIMES COMMITTED INVOLVING MINORS

Правовое государство: теория и практика
The article reveals the problems of assessing the reliability of evidence obtained during verbal and non-verbal investigative actions, as well as the features of the formation of minors’ testimony.
KHALIULLINA Aigul Faatovna
doaj   +1 more source

The Use of Special Knowledge by Defense in Economic Crime Investigations

Теория и практика судебной экспертизы, 2016
The paper examines actions taken by defense when financial and economic assessment is warranted in the course of economic crime investigation; the order of commission of financial and economic assessment by the investigator or court in order to establish
A. E. Galinskaya
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source