Results 71 to 80 of about 9,236,020 (355)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Knowledge Management and its Utilisation : an Overview [PDF]

, 2004
The paper covers different aspects of Knowledge Management(KM) and its applications. Stress is given to the relevance of KM for organizations. The paper considers KM as a cross-disciplinary domain. The importance of Librarians & Information professionals
Bhattacharya, Partha, Chaudhury, Pravin Kumar   +1 more
core  

Understanding knowledge hiding in organizations

Journal of Organizational Behavior, 2019
J Organ Behav. 2019;40:779–782. Summary In our introduction to this special issue on understanding knowledge hiding in organizations, we provide some context to how andwhy this phenomenon should be studied.
C. Connelly, M. Černe, A. Dysvik, Miha Škerlavaj   +3 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

University proceedings. Volga region. Social sciences

Известия высших учебных заведений. Поволжский регион: Общественные науки
Background. Low-quality medical equipment used in the provision of medical care can endanger not only health, but also human life. This determines the public danger of such attacks on human life and health. The detection of these crimes is complicated by
V.N. Semelev
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Specialist knowledge practices of craftsmen and clerics in Senegal

, 2014
Special Issue: Knowledge in Practice: Expertise and the Transmission of Knowledge. Guest Editor: Kai Kresse and Trevor H. J. MarchandThis article examines the specialized knowledge practices of two sets of culturally recognized ‘experts’ in Senegal ...
Dilley, Roy Martin
core   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

A review of the Knowledge Management Centre: conducted for the Economic and Human Development Department, City of Cape Town

, 2012
Following a study of the resources and services of the Knowledge Management Centre (KMC) of the Economic and Human Development Department (EHD) and a survey of a sample of users and potential users, the conclusion is that the KMC is NOT operating in a ...
Underwood, Peter G, Smith, Gretchen
core