Results 21 to 30 of about 160,209 (193)

Harmonic morphisms from the Grassmannians and their non-compact duals

, 2006
In this paper we give a unified framework for the construction of complex valued harmonic morphisms from the real, complex and quaternionic Grassmannians and their non-compact duals.
Gudmundsson, Sigmundur, Svensson, Martin
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Partial metric spaces with negative distances and fixed point theorems [PDF]

, 2015
In this paper we consider partial metric spaces in the sense of O'Neill. We introduce the notions of strong partial metric spaces and Cauchy functions.
Assaf, Samer, Pal, Koushik
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Special geometry of Euclidean supersymmetry II: hypermultiplets and the c-map

, 2005
We construct two new versions of the c-map which allow us to obtain the target manifolds of hypermultiplets in Euclidean theories with rigid N =2 supersymmetry.
, A. Strominger, A. Van Proeyen, A.V. Belitsky, B. de Wit, B. de Wit, B. Feix, C.M. Hull, Christoph Mayer, D. Kaledin, Frank Saueressig, K. Behrndt, K.S. Stelle, Thomas Mohaupt, V. Cort'es, V. Cortés, Vicente Cortés   +16 more
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Toric hyperkahler manifolds with quaternionic Kahler bases and supergravity solutions

, 2004
In the present work some examples of toric hyperkahler metrics in eight dimensions are constructed. First it is described how the Calderbank-Pedersen metrics arise as a consequence of the Joyce description of selfdual structures in four dimensions, the ...
Alvarez-Gaume, Andrei G. Zorin, Andrianopoli, Anguelova, Anguelova, Anguelova, Antoniadis, Ashtekar, Atiyah, Atiyah, Behrndt, Behrndt, Behrndt, Berger, Bielawski, Bryant, Calderbank, Fre, Galicki, Gauntlett, Gauntlett, Gibbons, Gibbons, Gibbons, Hitchin, Ishihara, Jarv, Jones, Joyce, Kraan, Kronheimer, Osvaldo P. Santillan, Park, Pedersen, Portugues, Przanowski, Santillan, Swann, Ward, Wit, Wit, Wit, Witten, Wolf   +43 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Causal Cones, Cone Preserving Transformations and Causal Structure in Special and General Theory of Relativity

, 2012
We present a short review of geometric and algebraic approach to causal cones and describe cone preserving transformations and their relationship with causal structure related to special and general theory of relativity.
Janardhan, Sujatha, Saraykar, R. V.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source