Results 31 to 40 of about 160,209 (193)
Sp(3) structures on 14-dimensional manifolds
, 2012 The present article investigates Sp(3) structures on 14-dimensional Riemannian manifolds, a continuation of the recent study of manifolds modeled on rank two symmetric spaces (here: SU(6)/Sp(3)). We derive topological criteria for the existence of such a
Agricola, Ilka +2 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
, 2000 In this paper we develop an axiomatic approach to coarse homology theories. We prove a uniqueness result concerning coarse homology theories on the category of `coarse CW-complexes'.
Baum +8 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
, 2013 We construct the first non-trivial examples of compact non-isometric Alexandrov spaces which are isospectral with respect to the Laplacian and not isometric to Riemannian orbifolds. This construction generalizes independent earlier results by the authors
Engel, Alexander, Weilandt, Martin
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Higher Teichm\"uller Spaces: from SL(2,R) to other Lie groups [PDF]
, 2011 The first part of this paper surveys several characterizations of Teichm\"uller space as a subset of the space of representation of the fundamental group of a surface into PSL(2,R).
Burger, Marc +2 more
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