Results 111 to 120 of about 800,165 (296)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Characterisation of the periodontal proteome in gingival crevicular fluid and saliva using SWATH-MS

Frontiers in Cellular and Infection Microbiology
IntroductionProteomic techniques are useful to analyse the periodontal proteome in gingival crevicular fluid (GCF) and saliva. However, few investigations have assessed and compared the GCF and salivary proteomes. Therefore, this research aims to analyse
Triana Blanco-Pintos, Alba Regueira-Iglesias, Berta Suárez-Rodríguez, Noelia Seijas-Otero, Marta Relvas, Susana B. Bravo, Carlos Balsa-Castro, Inmaculada Tomás   +7 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Randomised-crossover clinical trial on the substantivity of a single application of a gel containing chlorhexidine and o-cymen-5-ol on the oral biofilm and saliva

BMC Oral Health
Background No clinical trials have evaluated the antimicrobial activity and substantivity of gel formulations containing chlorhexidine (CHX) and cymenol. Objective To compare the in situ antimicrobial effect and substantivity of a new 0.20% CHX + cymenol
B. Suárez-Rodríguez, A. Regueira-Iglesias, T. Blanco-Pintos, A. Sánchez-Barco, N. Vila-Blanco, C. Balsa-Castro, M. J. Carreira, I. Tomás   +7 more
doaj   +1 more source

Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in JapanAJOG Global Reports at a Glance

AJOG Global Reports
Background: Time-lapse technology (TLT) has emerged as a significant advancement in the field of assisted reproductive technology (ART), providing continuous observation of embryos.
Mitsutoshi Yamada, MD, PhD, Kenji Ezoe, PhD, Satoshi Ueno, PhD, Osamu Yoshino, MD, PhD, Toshifumi Takahashi, MD, PhD   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

ANATOMICAL AND MORPHOLOGICAL FEATURES OF PELVIS IN THE SOMATOTYPE CLASSIFICATION BY J. TANNER OF THE FEMALE STUDENTS OF SPECIAL MEDICAL GROUP [PDF]

, 2016
Konstiantyn Buhaievskyi
openalex   +1 more source

Features of the health state of persons of the special medical group of higher education institutions of the city of Dnipr

, 2023
K. G. Kravchenko
openalex   +2 more sources