Results 121 to 130 of about 2,584,309 (298)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Randomised-crossover clinical trial on the substantivity of a single application of a gel containing chlorhexidine and o-cymen-5-ol on the oral biofilm and saliva

BMC Oral Health
Background No clinical trials have evaluated the antimicrobial activity and substantivity of gel formulations containing chlorhexidine (CHX) and cymenol. Objective To compare the in situ antimicrobial effect and substantivity of a new 0.20% CHX + cymenol
B. Suárez-Rodríguez, A. Regueira-Iglesias, T. Blanco-Pintos, A. Sánchez-Barco, N. Vila-Blanco, C. Balsa-Castro, M. J. Carreira, I. Tomás   +7 more
doaj   +1 more source

Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in JapanAJOG Global Reports at a Glance

AJOG Global Reports
Background: Time-lapse technology (TLT) has emerged as a significant advancement in the field of assisted reproductive technology (ART), providing continuous observation of embryos.
Mitsutoshi Yamada, MD, PhD, Kenji Ezoe, PhD, Satoshi Ueno, PhD, Osamu Yoshino, MD, PhD, Toshifumi Takahashi, MD, PhD   +4 more
doaj   +1 more source

Analysis of Care Coordination for Children with Special Health Care Needs: A Parent\u27s Perspective [PDF]

, 2017
Introduction. Care coordination involves organizing patient care activities and sharing information among all of the participants concerned with a patient\u27s care to achieve improved outcomes, a recent national focus.
Dalton, Kristen M, DiBella, Desiree N, Lee, Alan, Link, Heather, Maynes, Lisa, Morrison, Althea L, Schlauch, Adam Michael, Vecchio, Marc J, Wood, Paige M   +8 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Improving aquaaerobics as means of hydrorehabilitation of students of special medical groups

Physical education of students, 2011
Рассмотрены вопросы, которые связаны с оценкой внедрения аквааэробики в учебный процесс физического воспитания студентов с ослабленным здоровьем. В эксперименте приняли участие 76 студентов юридической академии. В исследовании использовались данные анкетного опроса студентов, анализа научно-методической литературы и собственного практического опыта ...
Balamutova N.M., Polozhiy V.M., Kyselev L.F.   +2 more
openaire   +3 more sources

Models of general practitioner services in residential aged care facilities [PDF]

Describes different models for general practice care for patients in residential aged care facilities. Background Provision of timely and high-quality general practitioner (GP) services to patients in residential aged care facilities (RACFs) is ...
Richard Reed
core