Results 71 to 80 of about 2,584,309 (298)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Мотивація до занять фізичним вихованням у студентів спеціальної медичної групи НТУ "ХПІ" [PDF]
, 2016 Статья посвящена актуальной на сегодняшний день проблеме повышения мотивации к занятиям физическим воспитанием студентов специальной медицинской группы.
Азаренкова, Любов Леонідівна +1 more
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Evaluating the effectiveness of undergraduate clinical education programs
Medical Education Online, 2020 Medical schools should use a variety of measures to evaluate the effectiveness of their clinical curricula. Both outcome measures and process measures should be included, and these can be organized according to the four-level training evaluation model ...
John W. Ragsdale +6 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Special Education 2000 : the implementation experience : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Policy at Massey University [PDF]
, 2003 Since 1877 the state has provided free, secular and compulsory education for most of the children of school age in New Zealand. In 1989 legislation was passed that gave the right to enrol and attend at the local school to all children.
Wills, Roderick Malcolm Campbell
core
Current trends in the health of children and young people in learning environments [PDF]
, 2013 Determined by the dynamics in the health of students and medical teams consisting of physical training in secondary schools. Analyzed the records in-depth inspection of magazines and leaflets health of 32484 schoolchildren of Chernigov for the period ...
S.V. Garkusha
core +2 more sources
DYNAMIC CONTROL OF LOAD IN SPECIAL MEDICAL GROUP STUDENTS DURING PE ACTIVITIES
Human Sport Medicine, 2020 Aim. The article aims to evaluate the effectiveness of dynamic control of the workload during PE activities in special medical group students (SMG) using heart rate (HR) monitors. Materials and methods. The research involved 30 students with chronic pathology of the organs of vision, respiratory, cardiovascular, musculoskeletal, nervous and ...
E Ketlerova, L Kodaneva
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source