Results 51 to 60 of about 6,739,211 (288)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bulletin of the Iranian Mathematical Society, 2022 AbstractIn this paper, Fourier transform of multivariate orthogonal polynomials on the simplex is presented. A new family of multivariate orthogonal functions is obtained using the Parseval’s identity and several recurrence relations are derived.
Esra Güldoğan Lekesiz +2 more
openaire +4 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Orthogonal Polynomials, Paraorthogonal Polynomials, and Point Perturbation [PDF]
, 2009 This thesis consists of three parts. Part 1 starts with an introduction to orthogonal polynomials, to be followed by some well-known theorems pertinent to the results we shall discuss.
Wong, Manwah Lilian
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AxiomsIn this paper, we investigate the problem of designing surface pencil pairs through Bertrand curves as iso-curvature lines in three-dimensional Euclidean space.
Haytham A. Ali, Awatif Al-Jedani
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Applications of q-Hermite Polynomials to Subclasses of Analytic and Bi-Univalent Functions
Fractal and Fractional, 2022 In mathematics, physics, and engineering, orthogonal polynomials and special functions play a vital role in the development of numerical and analytical approaches.
Caihuan Zhang +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Microscopic universality of complex matrix model correlation functions at weak non-Hermiticity [PDF]
, 2002 The microscopic correlation functions of non-chiral random matrix models with complex eigenvalues are analyzed for a wide class of non-Gaussian measures.
Akemann, G, Akemann, Gernot, Akemann, G.
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Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Advanced Engineering Materials, EarlyView.Copper‐based composites enhanced with carbon feature convenient mechanical properties and favorable electric conductivity. Processing via deformation and thermomechanical treatments can introduce advantageous microstructures further enhancing their performance. Herein, copper–graphene powder‐based composites are directly consolidated via rotary swaging
Radim Kocich +3 more
wiley +1 more source