Results 91 to 100 of about 3,787,339 (300)

Tense, Perspectival Properties, and Special Relativity

open access: yesManuscrito
Tensism is the view that tense is not merely a property of language and the mind (narrowly individuated), but of the world itself. Perspectivalism extends this idea to all perspectival properties be they person (e.g. first person vs.
Peter Ludlow
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Peer instruction to address alternative conceptions in Einstein's special relativity

open access: yesRevista Brasileira de Ensino de Física
In education, decades have been spent investigating what kind of beliefs and attitudes students may have in relation to learning. The relevance of these lies on the implications that it brings concerning students' alternative conceptions.
Manuel S. Alvarez-Alvarado   +2 more
doaj   +1 more source

Schwinger model à la Very Special Relativity

open access: yesPhysics Letters B, 2019
In this work, we show that Lorentz invariant theories in 1+1 dimensions admit new terms inspired by Very Special Relativity (VSR) theories. We have studied the Schwinger model in VSR.
Jorge Alfaro, Alex Soto
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Quantum gauge freedom in very special relativity

open access: yesNuclear Physics B, 2017
We demonstrate Yokoyama gaugeon formalism for the Abelian one-form gauge (Maxwell) as well as for Abelian two-form gauge theory in the very special relativity (VSR) framework.
Sudhaker Upadhyay, Prasanta K. Panigrahi
doaj   +1 more source

Tunneling confronts special relativity [PDF]

open access: yesJournal of Computational Methods in Sciences and Engineering, 2011
Superluminal signal velocity is widely assumed to confront Einstein causality and thus the Special Theory of Relativity (STR). Actually, there is only the tunneling mechanism known to permit superluminal signal velocities at present. The demonstrated negative group velocity experiments don't represent superluminal signal velocities.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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