Results 121 to 130 of about 2,733,176 (326)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley +1 more source
F1000ResearchBackground Tests of special relativity have been conducted over the past century with increasing accuracy and none have showed violations of Lorentz invariance.
Daniël Bischoff van Heemskerck
doaj
Generalised Einstein mass-variation formulae: I Subluminal relative frame velocities
Results in Physics, 2016 Much of the formalism in special relativity is intimately bound up with Einstein’s formula for the variation of mass m with its velocity v, namely m(v)=m0∗[1-(v/c)2]-1/2, where m is the mass, v the velocity, c denotes the speed of light and m0∗ denotes ...
James M. Hill, Barry J. Cox
doaj
A Direct Terrestrial Test of the Second Postulate of Special Relativity [PDF]
, 1963 T. Alväger +2 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Proposal for an experiment to test the simultaneity theorem of the special theory of relativity [PDF]
, 1965 Reinhold Fürth
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