Results 141 to 150 of about 3,787,339 (300)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Quantum Mechanics versus Special Relativity: A forgotten conflict [PDF]

open access: yes, 2008
Despite the widespread assumptions on the compatibility between non-relativistic quantum mechanics and special relativity, there still remains a considerable amount of unresolved problems to which few authors explicitly pay attention.
Alemañ-Berenguer, Rafael-Andrés   +1 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Twin Paradox and the Logical Foundation of Relativity Theory [PDF]

open access: yes, 2005
We study the foundation of space-time theory in the framework of first-order logic (FOL). Since the foundation of mathematics has been successfully carried through (via set theory) in FOL, it is not entirely impossible to do the same for space-time ...
István, Németi   +2 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Michelson, FitzGerald and Lorentz: the origins of relativity revisited [PDF]

open access: yes, 2003
It is argued that an unheralded moment marking the beginnings of relativity theory occurred in 1889, when G. F. FitzGerald, no doubt with the puzzling 1887 Michelson-Morley experiment fresh in mind, wrote to Heaviside about the possible effects of motion
Harvey R Brown, Brown, Harvey R.
core  

Modified particle lifetimes as a signature of deformed relativity

open access: yesPhysics Letters B
We demonstrate a compatibility between the relativity principle and the clock postulate in deformed special relativity, by identifying the relevant deformed Lorentz transformations in position space between arbitrary frames.
Pedro H. Morais   +4 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Coordinates, observables and symmetry in relativity [PDF]

open access: yes, 2007
We investigate the interplay and connections between symmetry properties of equations, the interpretation of coordinates, the construction of observables, and the existence of physical relativity principles in spacetime theories. Using the refined notion
Westman, Hans   +3 more
core  

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