Results 41 to 50 of about 1,947,567 (271)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A Dutch clinical practice guideline for paediatric palliative care: a systematic review and recommendations on psychosocial care including preloss and bereavement care

BMC Palliative Care
Background Children with life-threatening and life-limiting conditions and their families are confronted with many uncertainties, incremental losses, and difficult decisions.
Kim C. van Teunenbroek, Renée L. Mulder, A. A. Eduard Verhagen, Leontien C. M. Kremer, Jeanette. L. Falkenburg, Petra Honig-Mazer, Esther M. M. van den Bergh, Marijke C. Kars, Johannes M. A. Verheijden, Hester Rippen, Brigitt C. M. Borggreve, Eline M. Kochen, Erna M. C. Michiels, on behalf of the working groups psychosocial care, and preloss and bereavement care of the Dutch paediatric palliative care guideline   +13 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identifying the key components of providing spiritual care in the hospital: a scoping review study

BMC Palliative Care
Background Spiritual health refers to activities and methods that improve the quality of life and the health of spiritual performance. This study was conducted to identify the key components necessary for providing spiritual care in hospitals.
Parinaz Khalili Khouzani, Vahid Yazdi-Feyzabadi, Mohammad Setayesh, Mohammad Hossain Mehrolhassani, Rohaneh Rahimisadegh   +4 more
doaj   +1 more source

Physical Pictures of Transport in Heterogeneous Media: Advection-Dispersion, Random Walk and Fractional Derivative Formulations

, 2002
The basic conceptual picture and theoretical basis for development of transport equations in porous media are examined. The general form of the governing equations is derived for conservative chemical transport in heterogeneous geological formations, for
Anderson, Bear, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Bouchaud, Brian Berkowitz, Chandrasekhar, Compte, Compte, Compte, Compte, Cushman, Dagan, Deng, Eggleston, Feehley, Garabedian, Gelhar, Glimm, Gnedenko, Haggerty, Harvey, Harvey Scher, Hatano, Hilfer, Jespersen, Joseph Klafter, Kenkre, Kinzelbach, Klafter, Klafter, Klafter, Koltermann, Kosakowski, Labolle, Labolle, Li, Lévy, Lévy, Mantegna, Mantegna, Margolin, Margolin, Matheron, Metzler, Metzler, Metzler, Metzler, Neuman, Oldham, Oppenheim, Ralf Metzler, Rubin, Samko, Scheidegger, Scheidegger, Scher, Scher, Scher, Shlesinger, Shlesinger, Silliman, Sposito, Zhang, Zumofen   +68 more
core   +1 more source

The need of special technique in crisis management [PDF]

, 2015
Operation of special equipment is possible in crisis situations. It is because special equipment is designed for operation in non-standard often extreme conditions and situation, it is available, it has a high degree of crossing capability and it is ...
Dlugoš, Ivan, Kopecký, Ivan, Lipták, Peter, Štrba, Ján   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Machine learning model for prediction of palliative care phases in patients with advanced cancer: a retrospective study

BMC Palliative Care
Background Developing an accurate predictive model for palliative care phases is crucial for improving cancer patient management, enabling healthcare providers to identify those in need of specific care plans and streamlining decision-making process for ...
Junchen Guo, Yunyun Dai, Sishan Jiang, Junqingzhao Liu, Xianghua Xu, Yongyi Chen   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Saltatory drift in a randomly driven two-wave potential

, 2005
Dynamics of a classical particle in a one-dimensional, randomly driven potential is analysed both analytically and numerically. The potential considered here is composed of two identical spatially-periodic saw-tooth-like components, one of which is ...
, Ajdari A, Astumian R D, Curie M P, Feynman R P, G Oshanin, J Klafter, M Urbakh, Maxwell J C, Oshanin G Klafter J Urbakh M, von Smoluchowski M   +10 more
core   +1 more source