Results 51 to 60 of about 310,143 (254)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Alternative food in crisis situations

, 2019
The paper provides an overview of the current trends in alternative food for civilians as well as rescue teams during the initiation and further stages of crisis.
Novák, Luděk, Mauer, Pavel, Maňásek, Jaromír, Valášek, Pavel   +3 more
core   +1 more source

Numerical simulations of strong wind situations near the Mediteranean French Coast: comparison with FETCH data [PDF]

, 2003
A detailed analysis is made of some typical strong wind situations near the French Mediterranean coast. Special attention has been paid to the wind from the north-northwest in the Gulf of Lion, also called the mistral.
Pezzoli, Alessandro, TEDESCHI G., RESCH F., Tedeschi, G., Resch, F.   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Behaviors in Advance Care Planning and ACtions Survey (BACPACS): development and validation part 1

BMC Palliative Care, 2017
Background Although advance care planning (ACP) is fairly well understood, significant barriers to patient participation remain. As a result, tools to assess patient behaviour are required.
Aliya Kassam, Maureen L. Douglas, Jessica Simon, Shannon Cunningham, Konrad Fassbender, Marta Shaw, Sara N. Davison   +6 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Factors influencing GPs’ perception of specialised palliative homecare (SPHC) importance – results of a cross-sectional study

BMC Palliative Care, 2020
Background General Practitioners (GPs) are the main providers of primary palliative care (PPC). At the same time they are the main initiators of specialised palliative homecare (SPHC).
K. Stichling, M. Krause, B. Ditscheid, M. Hach, M. Jansky, M. Kaufmann, T. Lehmann, W. Meißner, F. Nauck, W. Schneider, S. Schulz, H. C. Vollmar, U. Wedding, J. Bleidorn, A. Freytag, the SAVOIR Study Group   +15 more
doaj   +1 more source

Conducting Business Activities in Special Conditions: Problems of Legal Regulation

peer reviewedThis article explores the problems of conducting business in conditions that differ from generally accepted standards and norms. Special conditions may include situations such as economic crises, natural disasters, martial law, or other ...
Stanislav, Sieriebriak, Sergii, Solodchenko, Maksym, Bespalov, KRAVTSOV, Serhii   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source