Results 31 to 40 of about 167,014,311 (222)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
KDHE Division of Environment Overview. [2013]
, 2013 application/pdf; "January 17, 2013."; Presentation before the Kansas Legislature, House Committee on Energy & Environment, presented by the Division of Environment, Kansas Department of Health and Environment.Presentation giving a comprehensive overview ...
Kansas. Division of Environment.
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Special Program (S2_B30_F4_29)
, 2021 A group of people listen to a speaker and take notes for a special ...
University of Akron
core +1 more source
Sea Will Rise, Barbuda Will Survive: Environment and Time Consciousness
Ecocene: Cappadocia Journal of Environmental Humanities, 2020 In this article, we examine the link between environmental consciousnesses and time consciousness. We argue that the way people think about time shapes their experience of climate change threats.
Sophia Perdikaris, Katie Rose Hejtmanek
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Environmental radiation surveillance in Kansas: July, 1983 thru June, 1984
, 1984 "Fall, 1984." "The Environmental Radiation.Surveillance Program is one of several radiological health programs in the Radiation Control Program of the Bureau of Air Quality and Radiation Control, Division of Environment, Kansas Department ...
Kansas Division of Environment.
core +1 more source
Ecocene: Cappadocia Journal of Environmental Humanities, 2020 This article proposes environmental memory as an approach to reframing environmental justice in transnational contexts through the work of U.S. author, William T. Vollmann.
C. Parker Krieg
doaj +1 more source