Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Identification of self-incompatibility in macadamia <i>(Macadamia</i> SPP.<i>)</i> using field-bagging and fluorescence microscopy. [PDF]
Front Plant SciKong G, Yu W.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Varieties of System Transformations and Their Structural Background Based on the IPS Model [PDF]
This study is the theoretical chapter of a planned book. This book, aims to contribute to the theoretical foundations of similarities and differences in the transformation of party-state systems.
Maria Csanadi
core
Advancing Soybean Improvement: Multi-Omics Strategies, Cutting-Edge Techniques, and Bioinformatics Innovations. [PDF]
Plants (Basel)Samanfar B.
europepmc +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
Special and Differential Treatment, The Multilateral Trading System and Economic Development in the 21st Century [PDF]
This paper was prepared for the joint ICTSD – GP International Dialogue entitled, Making Special & Differential Treatment More Effective and Responsive to Development Needs, held 6 & 7 May 2003, in Chavannes-de-bogis, Switzerland.Economic ...
Singh, Ajit
core +1 more source
Effects of Three Sweet Potato Varieties on the Development, Survival, and Reproduction of <i>Spodoptera frugiperda</i> Based on an Age-Stage, Two-Sex Life Table Analysis. [PDF]
InsectsWang Z +6 more
europepmc +1 more source