Results 21 to 30 of about 18,271 (281)

Testing the results of the training aimed at future preschool educators by means of the Microsoft Teams program in distance and mixed forms of teaching / learning

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2021
The article considers the specifics of teaching the discipline "Methods of Acquainting Children with Ukrainian Ethnography in Establishments of Preschool Education" in terms of distant and blended learning.
Rudenko Yuliia
doaj   +1 more source

Gender research from multiple disciplines: Profiles, commitments and interrelations in an interdisciplinary group

Mètode Science Studies Journal: Annual Review, 2017
One of the greatest difficulties in interdisciplinary work is being able to focus on a common project when efforts and hierarchies do not advance in the same direction.
Marine Buet
doaj   +1 more source

The spiritual dimension in the elderly from the model of gerotranscendence and its approach from Occupational Therapy: a literature review

Cadernos Brasileiros de Terapia Ocupacional, 2023
Introduction: The field of the study of ageing is familiar with a theoretical framework known as gerotranscendence. Gerotranscendence understands old age as the final stage of a natural progression towards maturity and wisdom.
Purificación Cintado Fernández, Manuel Lázaro Pulido   +1 more
doaj   +1 more source

CATS: Cas9-assisted tag switching. A high-throughput method for exchanging genomic peptide tags in yeast

BMC Genomics, 2020
Background The creation of arrays of yeast strains each encoding a different protein with constant tags is a powerful method for understanding how genes and their proteins control cell function.
Lisa K. Berry, Grace Heredge Thomas, Peter H. Thorpe   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Le patrimoine des arts du spectacle en France

In Situ
Specialised libraries in the field of the performing arts play a particular and precise role in the constitution, conservation and interpretation of the performing arts heritage. Sharing their documentary missions, these institutions can include museums,
Joël Huthwohl
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Bioprospecting for Genes Encoding Hydrocarbon-Degrading Enzymes from Metagenomic Samples Isolated from Northern Adriatic Sea Sediments

Food Technology and Biotechnology, 2018
Three metagenomic libraries were constructed using surface sediment samples from the northern Adriatic Sea. Two of the samples were taken from a highly polluted and an unpolluted site respectively.
Ranko Gacesa, Damir Baranasic, Antonio Starcevic, Janko Diminic, Marino Korlević, Mirjana Najdek, Maria Blažina, Davor Oršolić, Domagoj Kolesarić, Paul F. Long, John Cullum, Daslav Hranueli, Sandi Orlic, Jurica Zucko   +13 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source